Medical office space · data as of September 2026
Medical office space for lease in Santa Clarita Valley
29 buildings with 158,464 SF of medical space available across 58 listed spaces. The largest like group, five Class B buildings on NNN, asks a median $2.50/SF/month.
Class B buildings on NNN in Santa Clarita Valley ask a median $2.50/SF/month. In Antelope Valley, nearby, the same class on the same structure asks $2.00.
That's $15,000 a year on a 2,500 SF suite, between Class B buildings on NNN: five in Santa Clarita Valley and 11 in Antelope Valley, compared at the median (the middle building). The median Santa Clarita Valley building is nine years newer, 2004 against 1995, which may explain part of the gap. The Santa Clarita Valley group is a median 79% leased, against 70% for Antelope Valley. Trade area lines are drawn on a map, not in a lease, and a practice that could work in either has both to price. Each building counts once, at the middle of its published range.
The second thing to know is about location. Henry Mayo Newhall Hospital is 1.2 miles from the center of the trade area. The lease read: distance to a campus is the one thing about a suite you can't build, negotiate or fix later. Pay for the location you need, and make the buildings compete on everything else.
Put together: matched Class B NNN buildings in Antelope Valley nearby ask $0.50 less at the median, and Henry Mayo Newhall Hospital sits 1.2 miles out. The address is fixed the day you sign; almost everything else is negotiable. How often does your practice make the trip to Henry Mayo Newhall Hospital now?
Santa Clarita Valley at a glance
- Buildings
- 29
- Medical space available
- 158,464 SF
- Vacant now
- 122,784 SF
- Largest single space
- 12,066 SF
Asking rents by lease structure
- NNN$1.50–$2.77/SF/mo7 buildings
- Full Service$2.95–$3.05/SF/mo3 buildings
- Modified Gross$2.15–$4.16/SF/mo3 buildings
- Gross + Electric$1.95–$2.25/SF/mo1 building
13 buildings withhold pricing or don't publish it. Those numbers come from the landlords on request.
Full Service includes operating costs and utilities; NNN adds taxes, insurance and common-area costs on top of base rent; Modified Gross splits them. Compare structures, not just rates. These ranges span every building class and age; the questions below compare like with like.
Available spaces by size
- 1–2 rooms12
- 3–4 rooms19
- 5–7 rooms12
- 8–12 rooms7
- 13+ rooms4
Room counts assume 350 to 500 usable SF per exam room, with rentable area 10% to 20% above usable.
Building class
- Class A3
- Class B19
- Class C7
Hospitals within 5 miles
- Henry Mayo Newhall Hospital, Valencia1.2 mi
Straight-line miles from the center of the Santa Clarita Valley buildings to the Census Bureau geocode of each hospital's address on the CMS hospital list.
Buildings with medical space available
| Building | Class | Built | Medical space | Largest space | Fits | Asking rent | |
|---|---|---|---|---|---|---|---|
| 27200 Tourney Rd Tourney Pointe | B | 1983 | 31,397 SF5 spaces
| 12,066 SF | ~20–31 rooms | $2.95–$3.05/SF/mo Full Service | |
| 23838 Valencia Blvd The Atrium | B | 1995 | 15,271 SF6 spaces
| 6,618 SF | ~11–17 rooms | $2.50/SF/mo NNN | |
| 26650 The Old Rd Westridge Executive Plaza | B | 2004 | 10,984 SF3 spaces
| 5,781 SF | ~9–15 rooms | $2.95–$3.05/SF/mo Full Service | |
| 26415 Carl Boyer Dr Center Point Plaza | A | 2007 | 10,911 SF2 spaces
| 7,674 SF | ~12–19 rooms | Withheld ask us | |
| 23925-23961 Newhall Ranch Rd Bridgeport Marketplace | A | 2008 | 10,436 SF1 space
| 10,436 SF | ~17–27 rooms | $2.95/SF/mo Full Service | |
| 25751 McBean Pky Henry Mayo Newhall Memorial Health Foundation | B | 1989 | 7,788 SF2 spaces
| 6,136 SF | ~10–15 rooms | $2.85/SF/mo NNN · sublease | |
| 25950 McBean Pky Granary Square | B | 1984 | 7,014 SF1 space
| 7,014 SF | ~11–18 rooms | Withheld ask us | |
| 27421 Tourney Rd Medical Offices on Tourney | B | 2006 | 6,612 SF2 spaces
| 4,244 SF | ~7–11 rooms | $2.50/SF/mo NNN | |
| 24355 Lyons Ave Lyons Medical Office Building | B | 1989 | 6,345 SF2 spaces
| 5,021 SF | ~8–13 rooms | Withheld ask us | |
| 25050 Peachland Ave Plaza Posada Professional Office | B | 1975 | 5,516 SF4 spaces
| 2,054 SF | ~3–5 rooms | $2.50/SF/mo NNN | |
| 23501 Cinema Dr Cinema Professional Center | B | 2007 | 4,998 SF2 spaces
| 2,933 SF | ~4–7 rooms | $1.50/SF/mo NNN | |
| 23861 McBean Pky Building E | B | 1976 | 4,931 SF3 spaces
| 2,130 SF | ~3–5 rooms | Withheld ask us | |
| 22840 Soledad Canyon Rd | C | 1984 | 4,130 SF1 space
| 4,130 SF | ~6–10 rooms | $2.50/SF/mo NNN | |
| 25802 Hemingway Ave Stevenson Ranch Plaza | B | 2006 | 4,111 SF2 spaces
| 2,457 SF | ~4–6 rooms | Withheld ask us | |
| 23929 McBean Pky Building F | C | 1998 | 3,644 SF2 spaces
| 2,493 SF | ~4–6 rooms | Withheld ask us | |
| 26357 McBean Pky Santa Clarita Valley Medical Plaza | B | 2005 | 2,754 SF1 space
| 2,754 SF | ~4–7 rooms | Withheld ask us | |
| 27015-27025 Mcbean Pky | A | 2001 | 2,480 SF1 space
| 2,480 SF | ~4–6 rooms | Withheld ask us | |
| 23206 Lyons Ave | B | 1988 | 2,211 SF1 space
| 2,211 SF | ~3–5 rooms | Withheld ask us | |
| 26330 Diamond Pl | B | 2007 | 2,153 SF1 space
| 2,153 SF | ~3–5 rooms | Withheld ask us | |
| 25775 McBean Pky Valencia Medical Office Building | B | 1989 | 2,127 SF2 spaces
| 1,201 SF | ~2–3 rooms | Withheld ask us | |
| 23861 McBean Pky Building D | C | 1976 | 1,901 SF2 spaces
| 1,109 SF | ~1–2 rooms | $2.15/SF/mo Modified Gross | |
| 17970 Sierra Hwy | C | 1982 | 1,890 SF1 space
| 1,890 SF | ~3–4 rooms | $4.16/SF/mo Modified Gross | |
| 28200 Bouquet Canyon Rd Canyon Center | C | 1986 | 1,800 SF1 space
| 1,800 SF | ~3–4 rooms | $2.77/SF/mo NNN | |
| 18500 Via Princessa Bldg B | B | 2004 | 1,627 SF1 space
| 1,627 SF | ~2–4 rooms | $2.75/SF/mo NNN | |
| 19034-19042 Soledad Canyon Rd | B | 1974 | 1,529 SF2 spaces
| 813 SF | ~1–2 rooms | $1.95–$2.25/SF/mo Gross + Electric | |
| 27875 Smyth Dr | B | 2005 | 1,339 SF1 space
| 1,339 SF | ~2–3 rooms | $3.00/SF/mo NNN · sublease | |
| 27141 Hidaway Ave | C | 1981 | 1,290 SF1 space
| 1,290 SF | ~2–3 rooms | $2.45/SF/mo Modified Gross | |
| 23861 McBean Pky Building A | C | 1976 | 843 SF1 space
| 843 SF | ~1–2 rooms | Withheld ask us | |
| 21050 Centre Pointe Pky | B | 2004 | 432 SF4 spaces
| 108 SF | Withheld ask us |
Availability and asking rates change frequently and are subject to verification. Current terms are confirmed before any tour.
Compared to nearby
| Area | Buildings | Medical space | Published asking rents ($/SF/mo, buildings) |
|---|---|---|---|
| Santa Clarita Valley | 29 | 158,464 SF | NNN $1.50–$2.77 (7) · Full Service $2.95–$3.05 (3) · Modified Gross $2.15–$4.16 (3) |
| Western San Fernando Valley | 44 | 237,184 SF | Full Service $1.80–$3.75 (12) · Modified Gross $1.75–$4.40 (11) · NNN $2.00–$3.35 (6) |
| Eastern San Fernando Valley | 28 | 159,048 SF | Modified Gross $2.00–$3.45 (6) · Full Service $2.00–$4.00 (4) · NNN $1.70–$4.00 (3) |
| Antelope Valley | 23 | 100,686 SF | NNN $1.10–$2.75 (11) · Modified Gross $1.30–$2.30 (6) · Lease type not stated $2.30 (1) |
| Los Angeles overall | 849 | 6,324,965 SF | Modified Gross $1.22–$8.50 (206) · Full Service $1.15–$10.00 (176) · NNN $1.10–$7.74 (143) |
Lowest to highest published building asking rents, grouped by lease structure; the three most common structures are shown. Each range mixes building classes and ages. See the full rent trends report.
Questions about medical office space in Santa Clarita Valley
How many medical office buildings have space available in Santa Clarita Valley?
Santa Clarita Valley has 29 buildings with medical office space available as of September 2026: 158,464 SF across 58 listed spaces. Of that, 122,784 SF is marked vacant now, and the largest single space is 12,066 SF, about 20 to 31 exam rooms.
What do medical office leases cost in Santa Clarita Valley?
In Santa Clarita Valley, Class B buildings on NNN ask $1.50 to $2.75/SF/month, with a median of $2.50, across five buildings built from 1975 to 2007. Each building counts once, at the middle of its published range. Across North Los Angeles County, Class B buildings on NNN ask a median $2.25/SF/month. The remaining nine priced buildings sit in classes and structures with fewer than five buildings each, too few to call typical. Another 13 buildings post no asking rent; those landlords quote on request. Full Service includes operating costs and utilities, NNN adds taxes, insurance and common-area costs on top, and Modified Gross splits them, so compare total occupancy cost, not the headline rate.
How much space does a medical practice need in Santa Clarita Valley?
About 385 to 600 rentable square feet per exam room. That's 350 to 500 usable square feet (the room plus its share of waiting, work areas, storage, restrooms and halls), and leases are quoted in rentable square feet, which run 10% to 20% above usable in multi-tenant medical buildings. In Santa Clarita Valley, the listed spaces break down as 12 for 1 to 2 rooms, 19 for 3 to 4, 12 for 5 to 7, 7 for 8 to 12 and 4 for 13 or more.
Which hospitals are near Santa Clarita Valley?
Henry Mayo Newhall Hospital is the closest hospital, 1.2 miles from the center of the Santa Clarita Valley trade area. Distances are straight-line miles from the Census Bureau geocode of each hospital's address on the CMS hospital list.
How current is the Santa Clarita Valley availability?
It's from the September 2026 survey of medical office availability. Spaces lease and asking terms change between monthly pulls, so current availability, rent and tenant improvement allowance are confirmed with each landlord before any tour.
Send me what fits in Santa Clarita Valley
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Your advisor
Jamal Brown
Real Estate Broker · CA DRE #01780052
Jamal has spent more than 23 years in commercial real estate and has negotiated and audited more than 1,000 leases. He represents medical practices as tenants and buyers, never landlords, across Los Angeles, Orange County, San Diego and the Inland Empire. Every request sent through this site gets a reply within one business day.
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