Medical office space · data as of September 2026
Medical office space for lease in Antelope Valley
23 buildings with 100,686 SF of medical space available across 34 listed spaces. The largest like group, 11 Class B buildings on NNN, asks a median $2.00/SF/month.
Line up only the Class B buildings in Antelope Valley built in 1990 or later that quote NNN, and asking rents still run from $1.35 to $2.75/SF/month across all seven.
Put a size on it. Say a 2,500 SF suite, about 4 to 6 exam rooms. At $1.35 that's $3,375 a month; at $2.75 it's $6,875, or $42,000 more a year. The lowest is a 1995 building that's 25% leased; the highest went up in 2004 and is 47% leased. The full NNN list here, all Class B, runs $1.10 to $2.75 across 11 buildings built from 1979 to 2009. Each building counts once, at the middle of its published range. NNN puts taxes, insurance and common-area costs on top, and those differ by building too.
Here's the part that gets less attention. Only 2 of 34 listed spaces are sized for one or two exam rooms. From the real estate side, a small practice in a trade area of larger suites should look at shared and sublease space as well as direct leases.
Put together: even matched on class and age, Class B NNN asks in Antelope Valley run $1.35 to $2.75, and only 2 of 34 spaces suit one or two rooms. Paying for rooms you don't use is the quiet cost here. Would your practice share a suite if the terms were right?
Antelope Valley at a glance
- Buildings
- 23
- Medical space available
- 100,686 SF
- Vacant now
- 92,512 SF
- Largest single space
- 12,000 SF
Asking rents by lease structure
- NNN$1.10–$2.75/SF/mo11 buildings
- Modified Gross$1.30–$2.30/SF/mo6 buildings
- Lease type not stated$2.30/SF/mo1 building
5 buildings withhold pricing or don't publish it. Those numbers come from the landlords on request.
Full Service includes operating costs and utilities; NNN adds taxes, insurance and common-area costs on top of base rent; Modified Gross splits them. Compare structures, not just rates. These ranges span every building class and age; the questions below compare like with like.
Available spaces by size
- 1–2 rooms2
- 3–4 rooms14
- 5–7 rooms12
- 8–12 rooms5
- 13+ rooms1
Room counts assume 350 to 500 usable SF per exam room, with rentable area 10% to 20% above usable.
Building class
- Class B19
- Class C4
Hospitals within 5 miles
- Palmdale Regional Medical Center, Palmdale3.4 mi
- Antelope Valley Hospital, Lancaster4.1 mi
Straight-line miles from the center of the Antelope Valley buildings to the Census Bureau geocode of each hospital's address on the CMS hospital list.
Buildings with medical space available
| Building | Class | Built | Medical space | Largest space | Fits | Asking rent | |
|---|---|---|---|---|---|---|---|
| 38660 Medical Center Dr Palmdale Regional Medical Center | B | 2009 | 21,125 SF6 spaces
| 6,747 SF | ~11–17 rooms | $2.40/SF/mo NNN | |
| 2330 Mall Loop Rd Building 5 | B | 1995 | 12,000 SF1 space
| 12,000 SF | ~20–31 rooms | $1.35/SF/mo NNN | |
| 2140 E Palmdale Blvd Towne Square West | B | 1987 | 7,000 SF2 spaces
| 5,269 SF | ~8–13 rooms | $2.15/SF/mo NNN | |
| 3720 Sierra Hwy | B | 2007 | 6,738 SF1 space
| 6,738 SF | ~11–17 rooms | Withheld ask us | |
| 1753 W Avenue J Lancaster MOB | B | 2004 | 5,694 SF1 space
| 5,694 SF | ~9–14 rooms | $2.75/SF/mo NNN | |
| 867 W Lancaster Blvd | B | 1979 | 5,127 SF2 spaces
| 2,587 SF | ~4–6 rooms | $1.95/SF/mo NNN | |
| 2307-2323 E Palmdale Blvd | C | 1986 | 4,895 SF1 space
| 4,895 SF | ~8–12 rooms | Withheld ask us | |
| 1505 W Avenue J | B | 1980 | 4,215 SF3 spaces
| 1,600 SF | ~2–4 rooms | $1.50/SF/mo NNN | |
| 42442 10th St W | C | 1974 | 3,600 SF1 space
| 3,600 SF | ~6–9 rooms | $1.50/SF/mo Modified Gross | |
| 40015 Sierra Hwy Bldg B | B | 1990 | 3,267 SF1 space
| 3,267 SF | ~5–8 rooms | Withheld ask us | |
| 43860 10th Street W | B | 1997 | 3,000 SF2 spaces
| 1,500 SF | ~2–3 rooms | $2.00/SF/mo NNN | |
| 843 Auto Center Dr Building 2 | B | 2007 | 2,940 SF1 space
| 2,940 SF | ~4–7 rooms | $2.36/SF/mo NNN | |
| 41210 11th St Mountain View Medical Center | B | 1993 | 2,777 SF1 space
| 2,777 SF | ~4–7 rooms | $1.30/SF/mo Modified Gross | |
| 43845 10th St Phase V | C | 1980 | 2,600 SF1 space
| 2,600 SF | ~4–6 rooms | $1.40/SF/mo Modified Gross | |
| 43901-43981 15th St W | B | 1982 | 2,400 SF1 space
| 2,400 SF | ~4–6 rooms | Withheld ask us | |
| 44105 15th St W | B | 2003 | 2,364 SF2 spaces
| 1,840 SF | ~3–4 rooms | $2.30/SF/mo | |
| 39959 Sierra Hwy Bldg A | B | 1991 | 2,270 SF1 space
| 2,270 SF | ~3–5 rooms | Withheld ask us | |
| 520-540 W Palmdale Blvd West Palmdale Plaza | B | 1992 | 1,729 SF1 space
| 1,729 SF | ~2–4 rooms | $1.89/SF/mo NNN | |
| 44215 15th St W Antelope Valley Hospital Campus | B | 1988 | 1,628 SF1 space
| 1,628 SF | ~2–4 rooms | $1.55/SF/mo Modified Gross | |
| 3005 E Palmdale Blvd Fountain Plaza | B | 1987 | 1,420 SF1 space
| 1,420 SF | ~2–3 rooms | $1.10/SF/mo NNN | |
| 38425-38431 20th St E | C | 1955 | 1,385 SF1 space
| 1,385 SF | ~2–3 rooms | $1.50/SF/mo Modified Gross | |
| 44725 10th St W Sierra Medical Plaza | B | 1983 | 1,309 SF1 space
| 1,309 SF | ~2–3 rooms | $2.30/SF/mo Modified Gross | |
| 847 Auto Center Dr Building 5 | B | 2007 | 1,203 SF1 space
| 1,203 SF | ~2–3 rooms | $2.36/SF/mo NNN |
Availability and asking rates change frequently and are subject to verification. Current terms are confirmed before any tour.
Compared to nearby
| Area | Buildings | Medical space | Published asking rents ($/SF/mo, buildings) |
|---|---|---|---|
| Antelope Valley | 23 | 100,686 SF | NNN $1.10–$2.75 (11) · Modified Gross $1.30–$2.30 (6) · Lease type not stated $2.30 (1) |
| Santa Clarita Valley | 29 | 158,464 SF | NNN $1.50–$2.77 (7) · Full Service $2.95–$3.05 (3) · Modified Gross $2.15–$4.16 (3) |
| Eastern San Fernando Valley | 28 | 159,048 SF | Modified Gross $2.00–$3.45 (6) · Full Service $2.00–$4.00 (4) · NNN $1.70–$4.00 (3) |
| Western San Fernando Valley | 44 | 237,184 SF | Full Service $1.80–$3.75 (12) · Modified Gross $1.75–$4.40 (11) · NNN $2.00–$3.35 (6) |
| Los Angeles overall | 849 | 6,324,965 SF | Modified Gross $1.22–$8.50 (206) · Full Service $1.15–$10.00 (176) · NNN $1.10–$7.74 (143) |
Lowest to highest published building asking rents, grouped by lease structure; the three most common structures are shown. Each range mixes building classes and ages. See the full rent trends report.
Questions about medical office space in Antelope Valley
How many medical office buildings have space available in Antelope Valley?
Antelope Valley has 23 buildings with medical office space available as of September 2026: 100,686 SF across 34 listed spaces. Of that, 92,512 SF is marked vacant now, and the largest single space is 12,000 SF, about 20 to 31 exam rooms.
What do medical office leases cost in Antelope Valley?
In Antelope Valley, Class B buildings on NNN ask $1.10 to $2.75/SF/month, with a median of $2.00, across 11 buildings built from 1979 to 2009. Each building counts once, at the middle of its published range. Across North Los Angeles County, Class B buildings on NNN ask a median $2.25/SF/month. The remaining seven priced buildings sit in classes and structures with fewer than five buildings each, too few to call typical. Another five buildings post no asking rent; those landlords quote on request. Full Service includes operating costs and utilities, NNN adds taxes, insurance and common-area costs on top, and Modified Gross splits them, so compare total occupancy cost, not the headline rate.
How much space does a medical practice need in Antelope Valley?
About 385 to 600 rentable square feet per exam room. That's 350 to 500 usable square feet (the room plus its share of waiting, work areas, storage, restrooms and halls), and leases are quoted in rentable square feet, which run 10% to 20% above usable in multi-tenant medical buildings. In Antelope Valley, the listed spaces break down as 2 for 1 to 2 rooms, 14 for 3 to 4, 12 for 5 to 7, 5 for 8 to 12 and 1 for 13 or more.
Which hospitals are near Antelope Valley?
Palmdale Regional Medical Center is the closest hospital, 3.4 miles from the center of the Antelope Valley trade area. Also within 5 miles: Antelope Valley Hospital, Lancaster, 4.1 miles. Distances are straight-line miles from the Census Bureau geocode of each hospital's address on the CMS hospital list.
How current is the Antelope Valley availability?
It's from the September 2026 survey of medical office availability. Spaces lease and asking terms change between monthly pulls, so current availability, rent and tenant improvement allowance are confirmed with each landlord before any tour.
Send me what fits in Antelope Valley
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Your advisor
Jamal Brown
Real Estate Broker · CA DRE #01780052
Jamal has spent more than 23 years in commercial real estate and has negotiated and audited more than 1,000 leases. He represents medical practices as tenants and buyers, never landlords, across Los Angeles, Orange County, San Diego and the Inland Empire. Every request sent through this site gets a reply within one business day.
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