Medical office space · data as of September 2026
Medical office space for lease in San Bernardino
29 buildings with 194,489 SF of medical space available across 84 listed spaces. The largest like group, six Class B buildings on Modified Gross, asks a median $1.67/SF/month.
Landlords in San Bernardino quote six different lease structures this September: Modified Gross in 10 buildings, NNN in four and Full Service in two.
Modified Gross splits operating costs between landlord and tenant, lease by lease; NNN puts taxes, insurance and common-area costs on top of the rate; Full Service rolls operating costs and utilities into the rate. So a Modified Gross rate and a NNN rate can't be compared until both are converted to total occupancy cost (rent plus everything the lease adds on top). Modified Gross runs $1.59 to $2.90/SF/month here, NNN $1.15 to $2.25 and Full Service $1.55 to $2.00.
The second thing to know is about the buildings. Only 8 of 84 listed spaces are 4,200 SF or larger. From the real estate side, scarce large space is a reason to ask about two adjacent suites as well as one big one. Ask each landlord what's contiguous (next to each other on the same floor), not just what's listed.
Short version: landlords in San Bernardino quote six lease structures, and only 8 of 84 spaces are 4,200 SF or larger. Size, not price, is the constraint for a bigger practice here. Could your practice run across two adjacent suites, or does it need one?
San Bernardino at a glance
- Buildings
- 29
- Medical space available
- 194,489 SF
- Vacant now
- 180,117 SF
- Largest single space
- 15,879 SF
Asking rents by lease structure
- Modified Gross$1.45–$2.90/SF/mo10 buildings
- NNN$1.15–$2.25/SF/mo4 buildings
- Full Service$1.55–$2.00/SF/mo2 buildings
- Gross + Electric$1.50–$1.85/SF/mo1 building
- Gross + Utilities$1.53/SF/mo1 building
- Gross + Utilities & Janitorial$2.50/SF/mo1 building
- Lease type not stated$1.60–$1.68/SF/mo1 building
9 buildings withhold pricing or don't publish it. Those numbers come from the landlords on request.
Full Service includes operating costs and utilities; NNN adds taxes, insurance and common-area costs on top of base rent; Modified Gross splits them. Compare structures, not just rates. These ranges span every building class and age; the questions below compare like with like.
Available spaces by size
- 1–2 rooms26
- 3–4 rooms37
- 5–7 rooms13
- 8–12 rooms5
- 13+ rooms3
Room counts assume 350 to 500 usable SF per exam room, with rentable area 10% to 20% above usable.
Building class
- Class B22
- Class C7
Hospitals within 5 miles
- St. Bernardine Medical Center, San Bernardino2.8 mi
- Community Hospital of San Bernardino, San Bernardino2.8 mi
- Arrowhead Regional Medical Center, Colton3.6 mi
- Loma Linda University Medical Center, Loma Linda3.8 mi
- Loma Linda University Children's Hospital, Loma Linda3.8 mi
Straight-line miles from the center of the San Bernardino buildings to the Census Bureau geocode of each hospital's address on the CMS hospital list.
Buildings with medical space available
| Building | Class | Built | Medical space | Largest space | Fits | Asking rent | |
|---|---|---|---|---|---|---|---|
| 399 E Highland Ave St. Bernardine Medical Plaza (A) | B | 1971 | 55,044 SF30 spaces
| 6,510 SF | ~10–16 rooms | Withheld ask us | |
| 1800 Medical Center Dr Community Medical Plaza | B | 1996 | 33,897 SF3 spaces
| 15,879 SF | ~26–41 rooms | $1.63/SF/mo Modified Gross | |
| 2150 N Waterman Ave Waterman Medical Plaza | B | 1988 | 18,566 SF5 spaces
| 5,534 SF | ~9–14 rooms | Withheld ask us | |
| 9904 Bloomington Ave | C | 1995 | 9,000 SF1 space
| 9,000 SF | ~15–23 rooms | $1.25/SF/mo NNN | |
| 401 E Highland Ave St. Bernardine Medical Plaza (B) | B | 1972 | 8,759 SF4 spaces
| 3,266 SF | ~5–8 rooms | Withheld ask us | |
| 242 E Airport Dr Commerce Plaza | B | 1987 | 6,278 SF5 spaces
| 1,732 SF | ~2–4 rooms | $1.60/SF/mo Modified Gross | |
| 330 N D St | B | 1970 | 5,389 SF4 spaces
| 1,843 SF | ~3–4 rooms | $1.65–$1.75/SF/mo Modified Gross | |
| 1550 E Washington St | B | 1977 | 5,000 SF1 space
| 5,000 SF | ~8–12 rooms | $2.90/SF/mo Modified Gross | |
| 1023-1027 S Mt Vernon Ave Mt Vernon Business Center | B | 1982 | 4,559 SF2 spaces
| 3,270 SF | ~5–8 rooms | $1.50–$1.85/SF/mo Gross + Electric | |
| 328 E Commercial Rd Bldg A | B | 2007 | 4,200 SF1 space
| 4,200 SF | ~7–10 rooms | Withheld ask us | |
| 1830 Commercenter East | B | 1979 | 3,926 SF1 space
| 3,926 SF | ~6–10 rooms | $2.50/SF/mo Gross + Utilities & Janitorial | |
| 1799 N Waterman Ave Waterman Professional Building | B | 1968 | 3,900 SF3 spaces
| 2,000 SF | ~3–5 rooms | $1.58–$1.60/SF/mo Modified Gross | |
| 1850 N Riverside Ave St Bernardine Medical Plaza | B | 1993 | 3,729 SF1 space
| 3,729 SF | ~6–9 rooms | $2.25/SF/mo NNN | |
| 1850 S Waterman Ave | B | 1989 | 3,661 SF2 spaces
| 2,561 SF | ~4–6 rooms | $2.00/SF/mo Full Service | |
| 1430 E Cooley Dr Cooley Executive II | B | 1991 | 3,366 SF2 spaces
| 1,683 SF | ~2–4 rooms | $1.45–$2.41/SF/mo Modified Gross | |
| 290 N D St Vanir Tower | B | 1974 | 2,909 SF1 space
| 2,909 SF | ~4–7 rooms | Withheld ask us | |
| 2020 N Waterman De Leon Professional Building | C | 1969 | 2,891 SF3 spaces
| 1,145 SF | ~1–2 rooms | $1.65/SF/mo Modified Gross | |
| 2210 E Highland Ave | B | 1988 | 2,424 SF2 spaces
| 1,224 SF | ~2–3 rooms | Withheld ask us | |
| 2318-2354 Sterling Ave | B | 1979 | 2,200 SF1 space
| 2,200 SF | ~3–5 rooms | Withheld ask us | |
| 993 W Valley Blvd Bldg 100 | C | 1989 | 2,080 SF1 space
| 2,080 SF | ~3–5 rooms | $2.00/SF/mo Modified Gross | |
| 1800 N Western Ave | B | 1976 | 1,943 SF1 space
| 1,943 SF | ~3–5 rooms | Withheld ask us | |
| 3644-3694 E Highland Ave | B | 1990 | 1,880 SF1 space
| 1,880 SF | ~3–4 rooms | $1.15–$1.19/SF/mo NNN | |
| 1673-1675 N D St Hunt Professional Building | C | 1944 | 1,600 SF2 spaces
| 1,100 SF | ~1–2 rooms | $2.00–$2.10/SF/mo Modified Gross | |
| 12139 Mt Vernon Ave | C | 1971 | 1,568 SF1 space
| 1,568 SF | ~2–4 rooms | $1.50–$2.67/SF/mo Modified Gross | |
| 577 N D St Victor Kee Building | B | 1989 | 1,500 SF1 space
| 1,500 SF | ~2–3 rooms | Withheld ask us | |
| 22545 Barton Rd | C | 1989 | 1,300 SF1 space
| 1,300 SF | ~2–3 rooms | $1.53/SF/mo Gross + Utilities | |
| 1881 S Commercenter Drive East | C | 1980 | 1,219 SF2 spaces
| 625 SF | ~1 room | $1.60–$1.68/SF/mo | |
| 1396 Waterman Ave Waterman Office and Medical Buildings | B | 1955 | 1,021 SF1 space
| 1,021 SF | ~1–2 rooms | $1.15/SF/mo NNN | |
| 1003 E Cooley Dr Mount Vernon Plaza | B | 1982 | 680 SF1 space
| 680 SF | ~1 room | $1.55/SF/mo Full Service |
Availability and asking rates change frequently and are subject to verification. Current terms are confirmed before any tour.
Compared to nearby
| Area | Buildings | Medical space | Published asking rents ($/SF/mo, buildings) |
|---|---|---|---|
| San Bernardino | 29 | 194,489 SF | Modified Gross $1.45–$2.90 (10) · NNN $1.15–$2.25 (4) · Full Service $1.55–$2.00 (2) |
| Redlands and Loma Linda | 17 | 88,281 SF | NNN $1.10–$2.55 (8) · Modified Gross $1.50–$2.30 (4) · Gross + Utilities $1.87 (1) |
| Riverside | 16 | 61,169 SF | Modified Gross $1.60–$2.83 (8) · NNN $2.00–$2.50 (4) · Full Service $4.88 (1) |
| Moreno Valley and Perris | 9 | 33,938 SF | Full Service $2.00 (1) · Modified Gross $2.40–$2.70 (1) · NNN $2.00 (1) |
| Inland Empire overall | 219 | 1,107,256 SF | NNN $1.10–$3.25 (75) · Modified Gross $1.20–$3.83 (57) · Full Service $1.50–$10.00 (13) |
Lowest to highest published building asking rents, grouped by lease structure; the three most common structures are shown. Each range mixes building classes and ages. See the full rent trends report.
Questions about medical office space in San Bernardino
How many medical office buildings have space available in San Bernardino?
San Bernardino has 29 buildings with medical office space available as of September 2026: 194,489 SF across 84 listed spaces. Of that, 180,117 SF is marked vacant now, and the largest single space is 15,879 SF, about 26 to 41 exam rooms.
What do medical office leases cost in San Bernardino?
In San Bernardino, Class B buildings on Modified Gross ask $1.59 to $2.90/SF/month, with a median of $1.67, across six buildings built from 1968 to 1996. Each building counts once, at the middle of its published range. The remaining 14 priced buildings sit in classes and structures with fewer than five buildings each, too few to call typical. Another nine buildings post no asking rent; those landlords quote on request. Full Service includes operating costs and utilities, NNN adds taxes, insurance and common-area costs on top, and Modified Gross splits them, so compare total occupancy cost, not the headline rate.
How much space does a medical practice need in San Bernardino?
About 385 to 600 rentable square feet per exam room. That's 350 to 500 usable square feet (the room plus its share of waiting, work areas, storage, restrooms and halls), and leases are quoted in rentable square feet, which run 10% to 20% above usable in multi-tenant medical buildings. In San Bernardino, the listed spaces break down as 26 for 1 to 2 rooms, 37 for 3 to 4, 13 for 5 to 7, 5 for 8 to 12 and 3 for 13 or more.
Which hospitals are near San Bernardino?
St. Bernardine Medical Center is the closest hospital, 2.8 miles from the center of the San Bernardino trade area. Also within 5 miles: Community Hospital of San Bernardino, San Bernardino, 2.8 miles; Arrowhead Regional Medical Center, Colton, 3.6 miles; Loma Linda University Medical Center, Loma Linda, 3.8 miles; Loma Linda University Children's Hospital, Loma Linda, 3.8 miles. Distances are straight-line miles from the Census Bureau geocode of each hospital's address on the CMS hospital list.
How current is the San Bernardino availability?
It's from the September 2026 survey of medical office availability. Spaces lease and asking terms change between monthly pulls, so current availability, rent and tenant improvement allowance are confirmed with each landlord before any tour.
Send me what fits in San Bernardino
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Your advisor
Jamal Brown
Real Estate Broker · CA DRE #01780052
Jamal has spent more than 23 years in commercial real estate and has negotiated and audited more than 1,000 leases. He represents medical practices as tenants and buyers, never landlords, across Los Angeles, Orange County, San Diego and the Inland Empire. Every request sent through this site gets a reply within one business day.
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