Medical office space · data as of September 2026
Medical office space for lease in Uptown, Bankers Hill and Downtown
11 buildings with 91,377 SF of medical space available across 34 listed spaces. Seven buildings publish an asking rent; no class has five or more on one lease structure, too few to call a figure typical.
Scripps Mercy Hospital is 0.6 mile from the center of the Uptown, Bankers Hill and Downtown buildings, and UC San Diego Health Hillcrest - Hillcrest Medical Center is 0.8 mile.
That's straight-line distance from the middle of 11 buildings, so individual buildings sit closer or farther. Across the trade area, seven buildings publish an asking rent, and four post no asking rent. Most of the inventory sits on 3rd Ave, 4th Ave and 5th Ave: 7 of 11 buildings.
The second thing to know is about the buildings. Only 3 of 34 listed spaces are 4,200 SF or larger. The lease read: a practice that needs eight rooms or more here is shopping from a short list, and the landlords on it know that. Start earlier than feels necessary, and keep a second trade area in play.
Put together: two hospitals sit within 0.8 mile of the center, and only 3 of 34 spaces are 4,200 SF or larger. Size, not price, is the constraint for a bigger practice here. Could your practice run across two adjacent suites, or does it need one?
Uptown, Bankers Hill and Downtown at a glance
- Buildings
- 11
- Medical space available
- 91,377 SF
- Vacant now
- 90,053 SF
- Largest single space
- 12,537 SF
Asking rents by lease structure
- Modified Gross$2.25–$3.65/SF/mo3 buildings
- NNN$1.95–$2.60/SF/mo3 buildings
- Gross + Utilities$2.35–$3.25/SF/mo1 building
4 buildings withhold pricing or don't publish it. Those numbers come from the landlords on request.
Full Service includes operating costs and utilities; NNN adds taxes, insurance and common-area costs on top of base rent; Modified Gross splits them. Compare structures, not just rates. These ranges span every building class and age; the questions below compare like with like.
Available spaces by size
- 1–2 rooms5
- 3–4 rooms18
- 5–7 rooms8
- 8–12 rooms1
- 13+ rooms2
Room counts assume 350 to 500 usable SF per exam room, with rentable area 10% to 20% above usable.
Building class
- Class A2
- Class B6
- Class C3
Hospitals within 5 miles
- Scripps Mercy Hospital, San Diego0.6 mi
- UC San Diego Health Hillcrest - Hillcrest Medical Center, San Diego0.8 mi
- Nmc San Diego (military), San Diego1.6 mi
- Sharp Coronado Hospital and Hlthcr Center, Coronado3.4 mi
- Rady Children's Hospital - San Diego (children's), San Diego3.9 mi
Straight-line miles from the center of the Uptown, Bankers Hill and Downtown buildings to the Census Bureau geocode of each hospital's address on the CMS hospital list.
Buildings with medical space available
| Building | Class | Built | Medical space | Largest space | Fits | Asking rent | |
|---|---|---|---|---|---|---|---|
| 4060 4th Ave Mercy Medical Building | B | 1979 | 27,929 SF9 spaces
| 12,537 SF | ~20–32 rooms | Withheld ask us | |
| 550 Washington St | B | 1966 | 18,361 SF10 spaces
| 3,299 SF | ~5–8 rooms | $2.60/SF/mo Modified Gross | |
| 3500 5th Ave Webster Bldg | B | 1971 | 15,993 SF4 spaces
| 6,559 SF | ~10–17 rooms | $2.60/SF/mo NNN | |
| 3960 3rd Ave Stand Alone Medical Facility | C | 1972 | 7,975 SF1 space
| 7,975 SF | ~13–20 rooms | $1.95/SF/mo NNN | |
| 2918 5th Ave Fifth & Palm Building | C | 1981 | 5,182 SF2 spaces
| 2,591 SF | ~4–6 rooms | $3.65/SF/mo Modified Gross | |
| 3935 1st Ave | C | 1984 | 4,000 SF1 space
| 4,000 SF | ~6–10 rooms | $2.25/SF/mo Modified Gross | |
| 3969 4th Ave | B | 1982 | 3,147 SF2 spaces
| 1,602 SF | ~2–4 rooms | $2.25/SF/mo NNN | |
| 3955-3995 5th Ave Village Hillcrest | A | 1993 | 2,862 SF1 space
| 2,862 SF | ~4–7 rooms | Withheld ask us | |
| 450 A St | B | 1986 | 2,170 SF1 space
| 2,170 SF | ~3–5 rooms | $2.35–$3.25/SF/mo Gross + Utilities | |
| 2131 3rd Ave | A | 1956 | 1,905 SF1 space
| 1,905 SF | ~3–4 rooms | Withheld ask us | |
| 4033 3rd Ave Hillcrest Medical Center | B | 1990 | 1,853 SF2 spaces
| 967 SF | ~1–2 rooms | Withheld ask us |
Availability and asking rates change frequently and are subject to verification. Current terms are confirmed before any tour.
Compared to nearby
| Area | Buildings | Medical space | Published asking rents ($/SF/mo, buildings) |
|---|---|---|---|
| Uptown, Bankers Hill and Downtown | 11 | 91,377 SF | Modified Gross $2.25–$3.65 (3) · NNN $1.95–$2.60 (3) · Gross + Utilities $2.35–$3.25 (1) |
| Mission Valley | 13 | 99,719 SF | Gross + Electric $1.75–$2.65 (3) · Full Service $2.15–$2.90 (2) · Gross + Utilities $2.95 (2) |
| Kearny Mesa | 17 | 144,490 SF | Modified Gross $1.60–$3.50 (4) · NNN $2.75 (4) · Full Service $3.35 (1) |
| San Diego overall | 246 | 2,136,242 SF | NNN $1.25–$4.25 (41) · Modified Gross $1.50–$5.28 (34) · Gross + Electric $1.75–$4.45 (13) |
Lowest to highest published building asking rents, grouped by lease structure; the three most common structures are shown. Each range mixes building classes and ages. See the full rent trends report.
Questions about medical office space in Uptown, Bankers Hill and Downtown
How many medical office buildings have space available in Uptown, Bankers Hill and Downtown?
Uptown, Bankers Hill and Downtown has 11 buildings with medical office space available as of September 2026: 91,377 SF across 34 listed spaces. Of that, 90,053 SF is marked vacant now, and the largest single space is 12,537 SF, about 20 to 32 exam rooms.
What do medical office leases cost in Uptown, Bankers Hill and Downtown?
In Uptown, Bankers Hill and Downtown, seven buildings publish an asking rent with a named lease structure, but no class has five or more on one structure, too few to call any figure typical: Class C on Modified Gross in two, Class B on NNN in two and Class B on Gross + Utilities in one. Another four buildings post no asking rent; those landlords quote on request. Full Service includes operating costs and utilities, NNN adds taxes, insurance and common-area costs on top, and Modified Gross splits them, so compare total occupancy cost, not the headline rate.
How much space does a medical practice need in Uptown, Bankers Hill and Downtown?
About 385 to 600 rentable square feet per exam room. That's 350 to 500 usable square feet (the room plus its share of waiting, work areas, storage, restrooms and halls), and leases are quoted in rentable square feet, which run 10% to 20% above usable in multi-tenant medical buildings. In Uptown, Bankers Hill and Downtown, the listed spaces break down as 5 for 1 to 2 rooms, 18 for 3 to 4, 8 for 5 to 7, 1 for 8 to 12 and 2 for 13 or more.
Which hospitals are near Uptown, Bankers Hill and Downtown?
Scripps Mercy Hospital is the closest hospital, 0.6 mile from the center of the Uptown, Bankers Hill and Downtown trade area. Also within 5 miles: UC San Diego Health Hillcrest - Hillcrest Medical Center, San Diego, 0.8 mile; Nmc San Diego (military), San Diego, 1.6 miles; Sharp Coronado Hospital and Hlthcr Center, Coronado, 3.4 miles; Rady Children's Hospital - San Diego (children's), San Diego, 3.9 miles. Distances are straight-line miles from the Census Bureau geocode of each hospital's address on the CMS hospital list.
How current is the Uptown, Bankers Hill and Downtown availability?
It's from the September 2026 survey of medical office availability. Spaces lease and asking terms change between monthly pulls, so current availability, rent and tenant improvement allowance are confirmed with each landlord before any tour.
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Your advisor
Jamal Brown
Real Estate Broker · CA DRE #01780052
Jamal has spent more than 23 years in commercial real estate and has negotiated and audited more than 1,000 leases. He represents medical practices as tenants and buyers, never landlords, across Los Angeles, Orange County, San Diego and the Inland Empire. Every request sent through this site gets a reply within one business day.
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