Medical office space · data as of September 2026
Medical office space for lease in Mission Valley
13 buildings with 99,719 SF of medical space available across 28 listed spaces. Nine buildings publish an asking rent; no class has five or more on one lease structure, too few to call a figure typical.
Mission Valley's listed medical space runs large this September: only 1 of 28 spaces suits one or two exam rooms.
A one- or two-room practice needs roughly 385 to 1,200 rentable SF. Here, 19 spaces fit three to seven rooms and eight run to eight or more, which leaves a small practice choosing between a short list and extra rooms.
One more fact changes the read. Landlords here quote five lease structures: Gross + Electric in three buildings, at $1.75 to $2.65/SF/month; Full Service in two buildings and Gross + Utilities in two buildings. From the real estate side, the structure is part of the price. On a Modified Gross quote, ask exactly which operating costs are yours; the split is written lease by lease. Every lease structure should be approached differently during Operating Expense reconciliations.
So: only 1 of 28 spaces suits one or two rooms, and landlords there quote five lease structures. Convert every quote to the same basis before any number looks cheap. Is your current lease Full Service, NNN or Modified Gross, and do you know what it costs all in?
Mission Valley at a glance
- Buildings
- 13
- Medical space available
- 99,719 SF
- Vacant now
- 62,366 SF
- Largest single space
- 9,085 SF
Asking rents by lease structure
- Gross + Electric$1.75–$2.65/SF/mo3 buildings
- Full Service$2.15–$2.90/SF/mo2 buildings
- Gross + Utilities$2.95/SF/mo2 buildings
- Gross + Electric & Janitorial$1.50–$2.00/SF/mo1 building
- Modified Gross$2.25/SF/mo1 building
3 buildings withhold pricing or don't publish it. Those numbers come from the landlords on request.
Full Service includes operating costs and utilities; NNN adds taxes, insurance and common-area costs on top of base rent; Modified Gross splits them. Compare structures, not just rates. These ranges span every building class and age; the questions below compare like with like.
Available spaces by size
- 1–2 rooms1
- 3–4 rooms11
- 5–7 rooms8
- 8–12 rooms5
- 13+ rooms3
Room counts assume 350 to 500 usable SF per exam room, with rentable area 10% to 20% above usable.
Building class
- Class A1
- Class B10
- Class C2
Hospitals within 5 miles
- Scripps Mercy Hospital, San Diego1.8 mi
- Rady Children's Hospital - San Diego (children's), San Diego1.8 mi
- UC San Diego Health Hillcrest - Hillcrest Medical Center, San Diego1.8 mi
- Sharp Memorial Hospital, San Diego1.9 mi
- Kaiser Foundation Hospital - San Diego, San Diego3.2 mi
Straight-line miles from the center of the Mission Valley buildings to the Census Bureau geocode of each hospital's address on the CMS hospital list.
Buildings with medical space available
| Building | Class | Built | Medical space | Largest space | Fits | Asking rent | |
|---|---|---|---|---|---|---|---|
| 5333 Mission Center Rd | B | 1974 | 32,912 SF7 spaces
| 7,499 SF | ~12–19 rooms | $2.95/SF/mo Gross + Utilities | |
| 9095 Rio San Diego Dr Rio Vista Medical Plaza | B | 2005 | 17,693 SF5 spaces
| 8,946 SF | ~14–23 rooms | Withheld ask us | |
| 5353 Mission Center Rd | B | 1974 | 12,380 SF2 spaces
| 9,085 SF | ~15–23 rooms | $2.95/SF/mo Gross + Utilities | |
| 5030 Camino de la Siesta Mission Courtyard | B | 1980 | 9,326 SF4 spaces
| 3,172 SF | ~5–8 rooms | $2.65/SF/mo Gross + Electric | |
| 1545 Hotel Cir S Mission Grove Office Park | B | 1984 | 7,542 SF2 spaces
| 4,232 SF | ~7–10 rooms | $1.81–$1.89/SF/mo Gross + Electric | |
| 2810 Camino Del Rio S | B | 1983 | 5,700 SF1 space
| 5,700 SF | ~9–14 rooms | Withheld ask us | |
| 591 Camino de la Reina Tower 591 | A | 1972 | 3,830 SF1 space
| 3,830 SF | ~6–9 rooms | $3.25/SF/mo Gross + Electric · sublease | |
| 10850 Baroque Ln | C | 1991 | 2,327 SF1 space
| 2,327 SF | ~3–6 rooms | Withheld ask us | |
| 2878 camino del rio S Interstate Plaza II | B | 1989 | 1,907 SF1 space
| 1,907 SF | ~3–4 rooms | $2.15–$2.40/SF/mo Full Service | |
| 3633 Camino del Rio S Riverview Center Professional Building | B | 1982 | 1,900 SF1 space
| 1,900 SF | ~3–4 rooms | $2.25/SF/mo Modified Gross | |
| 2020 Camino del Rio N Plaza 2020 | B | 1970 | 1,748 SF1 space
| 1,748 SF | ~2–4 rooms | $2.85–$2.90/SF/mo Full Service | |
| 5920 Friars Rd Park Place Plaza | B | 1987 | 1,553 SF1 space
| 1,553 SF | ~2–4 rooms | $1.75/SF/mo Gross + Electric | |
| 2515 Camino del Rio S | C | 1976 | 901 SF1 space
| 901 SF | ~1–2 rooms | $1.50–$2.00/SF/mo Gross + Electric & Janitorial |
Availability and asking rates change frequently and are subject to verification. Current terms are confirmed before any tour.
Compared to nearby
| Area | Buildings | Medical space | Published asking rents ($/SF/mo, buildings) |
|---|---|---|---|
| Mission Valley | 13 | 99,719 SF | Gross + Electric $1.75–$2.65 (3) · Full Service $2.15–$2.90 (2) · Gross + Utilities $2.95 (2) |
| Kearny Mesa | 17 | 144,490 SF | Modified Gross $1.60–$3.50 (4) · NNN $2.75 (4) · Full Service $3.35 (1) |
| Uptown, Bankers Hill and Downtown | 11 | 91,377 SF | Modified Gross $2.25–$3.65 (3) · NNN $1.95–$2.60 (3) · Gross + Utilities $2.35–$3.25 (1) |
| College Area | 15 | 75,453 SF | Modified Gross $2.35 (5) · NNN $1.25–$3.50 (5) · Gross + Utilities & Janitorial $1.75 (1) |
| San Diego overall | 246 | 2,136,242 SF | NNN $1.25–$4.25 (41) · Modified Gross $1.50–$5.28 (34) · Gross + Electric $1.75–$4.45 (13) |
Lowest to highest published building asking rents, grouped by lease structure; the three most common structures are shown. Each range mixes building classes and ages. See the full rent trends report.
Questions about medical office space in Mission Valley
How many medical office buildings have space available in Mission Valley?
Mission Valley has 13 buildings with medical office space available as of September 2026: 99,719 SF across 28 listed spaces. Of that, 62,366 SF is marked vacant now, and the largest single space is 9,085 SF, about 15 to 23 exam rooms.
What do medical office leases cost in Mission Valley?
In Mission Valley, nine buildings publish an asking rent with a named lease structure, but no class has five or more on one structure, too few to call any figure typical: Class B on Gross + Electric in three, Class B on Full Service in two and Class B on Gross + Utilities in two. Another three buildings post no asking rent; those landlords quote on request. Full Service includes operating costs and utilities, NNN adds taxes, insurance and common-area costs on top, and Modified Gross splits them, so compare total occupancy cost, not the headline rate.
How much space does a medical practice need in Mission Valley?
About 385 to 600 rentable square feet per exam room. That's 350 to 500 usable square feet (the room plus its share of waiting, work areas, storage, restrooms and halls), and leases are quoted in rentable square feet, which run 10% to 20% above usable in multi-tenant medical buildings. In Mission Valley, the listed spaces break down as 1 for 1 to 2 rooms, 11 for 3 to 4, 8 for 5 to 7, 5 for 8 to 12 and 3 for 13 or more.
Which hospitals are near Mission Valley?
Scripps Mercy Hospital is the closest hospital, 1.8 miles from the center of the Mission Valley trade area. Also within 5 miles: Rady Children's Hospital - San Diego (children's), San Diego, 1.8 miles; UC San Diego Health Hillcrest - Hillcrest Medical Center, San Diego, 1.8 miles; Sharp Memorial Hospital, San Diego, 1.9 miles; Kaiser Foundation Hospital - San Diego, San Diego, 3.2 miles. Distances are straight-line miles from the Census Bureau geocode of each hospital's address on the CMS hospital list.
How current is the Mission Valley availability?
It's from the September 2026 survey of medical office availability. Spaces lease and asking terms change between monthly pulls, so current availability, rent and tenant improvement allowance are confirmed with each landlord before any tour.
Send me what fits in Mission Valley
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Your advisor
Jamal Brown
Real Estate Broker · CA DRE #01780052
Jamal has spent more than 23 years in commercial real estate and has negotiated and audited more than 1,000 leases. He represents medical practices as tenants and buyers, never landlords, across Los Angeles, Orange County, San Diego and the Inland Empire. Every request sent through this site gets a reply within one business day.
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