Medical office space · data as of September 2026
5333 Mission Center Rd, San Diego
7 medical office spaces listed, 32,912 SF in all, largest 7,499 SF (about 12 to 19 exam rooms). Five of them are vacant now. Asking $2.95/SF/mo on a Gross + Utilities basis.
Listed spaces at 5333 Mission Center Rd
| Space | Use | Term |
|---|---|---|
| Suite 105 · 6,653 SF · available now | Office/Medical | Negotiable |
| Suite 220 · 5,649 SF · available now | Office/Medical | Negotiable |
| Suite 200 · 5,213 SF · available now | Office/Medical | Negotiable |
| Suite 240 · 3,960 SF · available now | Office/Medical | Negotiable |
| Suite 300 · 7,499 SF · available Mar 2027 | Office/Medical | Negotiable |
| Suite 358 · 2,687 SF · available in 30 days | Office/Medical | Negotiable |
| Suite 350 · 1,251 SF · available now | Office/Medical | Negotiable |
Sizes are rentable square feet. Listed with the building as of September 2026. Availability, asking terms and tenant improvement allowance are confirmed with the landlord before any tour.
- Medical space listed
- 32,912 SF
- Largest space
- 7,499 SF
- Fits
- ~12–19 rooms
- Vacant now
- 5 of 7
Asking rent and building facts
Asking rent
- Gross + Utilities$2.95/SF/mobuilding asking range
Mission Valley for comparison
- Gross + Electric$1.75–$2.65/SF/mo3 buildings
- Full Service$2.15–$2.90/SF/mo2 buildings
- Gross + Utilities$2.95/SF/mo2 buildings
- Gross + Electric & Janitorial$1.50–$2.00/SF/mo1 building
- Modified Gross$2.25/SF/mo1 building
Lowest to highest published building asking rents in Mission Valley, grouped by lease structure. Full Service includes operating costs and utilities; NNN adds taxes, insurance and common-area costs; Modified Gross splits them.
Building
- Building classClass B
- Built1974, renovated 2005
- Stories3
- Rentable building area64,190 SF
- Parking ratio4.00 per 1,000 SF
- Leased65%
Hospitals near 5333 Mission Center Rd
- UC San Diego Health Hillcrest - Hillcrest Medical Center, San Diego1.4 mi
- Scripps Mercy Hospital, San Diego1.5 mi
- Rady Children's Hospital - San Diego (children's), San Diego1.9 mi
Straight-line miles from the Census Bureau geocode of each hospital's address on the CMS hospital list.
Other buildings with medical space in Mission Valley
- 5353 Mission Center Rd 12,380 SF · $2.95/SF/mo
- 2020 Camino del Rio N Plaza 2020 1,748 SF · $2.85–$2.90/SF/mo
- 591 Camino de la Reina Tower 591 3,830 SF · $3.25/SF/mo
- 5030 Camino de la Siesta Mission Courtyard 9,326 SF · $2.65/SF/mo
See every building in the Mission Valley trade area guide.
Questions about 5333 Mission Center Rd
What medical office space is available at 5333 Mission Center Rd?
5333 Mission Center Rd in San Diego lists 7 medical office spaces, 32,912 SF in all, as of September 2026: Suite 105 · 6,653 SF · available now, Suite 220 · 5,649 SF · available now, Suite 200 · 5,213 SF · available now, Suite 240 · 3,960 SF · available now, Suite 300 · 7,499 SF · available Mar 2027, Suite 358 · 2,687 SF · available in 30 days. Sizes are rentable square feet. Of those, five are vacant now.
What is the asking rent at 5333 Mission Center Rd?
$2.95/SF/mo, on a Gross + Utilities basis, as published for this Class B building, built in 1974 (renovated 2005).
How many exam rooms fit in the largest space at 5333 Mission Center Rd?
About 12 to 19. The largest listed space is 7,499 SF, and planning runs 385 to 600 rentable SF per exam room (350 to 500 usable, plus a 10% to 20% load factor, the share of common areas billed to each tenant). Plumbing, ADA restrooms and HVAC decide whether that count works in a building that wasn't built for exam rooms. This one dates to 1974, renovated 2005.
Which hospitals are near 5333 Mission Center Rd?
UC San Diego Health Hillcrest - Hillcrest Medical Center is the closest, 1.4 miles away. Also nearby: Scripps Mercy Hospital, San Diego, 1.5 miles; Rady Children's Hospital - San Diego (children's), San Diego, 1.9 miles. Distances are straight-line miles to each hospital's address on the CMS hospital list.
Is the availability at 5333 Mission Center Rd current?
It's from the September 2026 survey of medical office availability. Availability, rent and tenant improvement allowance are confirmed with the landlord before any tour.
Ask about 5333 Mission Center Rd
Send your size and timing. Live availability and terms for this building come back within one business day.
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Your advisor
Jamal Brown
Real Estate Broker · CA DRE #01780052
Jamal has spent more than 23 years in commercial real estate and has negotiated and audited more than 1,000 leases. He represents medical practices as tenants and buyers, never landlords, across Los Angeles, Orange County, San Diego and the Inland Empire. Every request sent through this site gets a reply within one business day.
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