Medical office space · data as of September 2026
Medical office space for lease in National City and Southeast San Diego
5 buildings with 18,772 SF of medical space available across 11 listed spaces. Two buildings publish an asking rent; no class has five or more on one lease structure, too few to call a figure typical.
Paradise Valley Hospital sits 0.7 mile from the center of the National City and Southeast San Diego trade area.
That's straight-line distance from the middle of five buildings, so individual buildings sit closer or farther. Across the trade area, two buildings publish an asking rent, and three post no asking rent. Of the five buildings, 2 sit on Euclid Ave.
The second thing to know is about price. Of the five buildings, three post no asking rent. The lease read: get a number from every building worth a tour, posted or not, before you pick a favorite. A landlord who knows you're only comparing posted rents knows exactly who it's competing with.
Short version: Paradise Valley Hospital sits 0.7 mile out, and three of five buildings in National City and Southeast San Diego post no rent. The numbers that matter here come on request. Of the buildings on your short list, how many have given you a number in writing?
National City and Southeast San Diego at a glance
- Buildings
- 5
- Medical space available
- 18,772 SF
- Vacant now
- 13,885 SF
- Largest single space
- 4,272 SF
Asking rents by lease structure
- Full Service$2.42–$2.54/SF/mo2 buildings
3 buildings withhold pricing or don't publish it. Those numbers come from the landlords on request.
Full Service includes operating costs and utilities; NNN adds taxes, insurance and common-area costs on top of base rent; Modified Gross splits them. Compare structures, not just rates. These ranges span every building class and age; the questions below compare like with like.
Available spaces by size
- 1–2 rooms3
- 3–4 rooms5
- 5–7 rooms2
- 8–12 rooms1
- 13+ rooms0
Room counts assume 350 to 500 usable SF per exam room, with rentable area 10% to 20% above usable.
Building class
- Class B2
- Class C3
Hospitals within 5 miles
- Paradise Valley Hospital, National City0.7 mi
- Nmc San Diego (military), San Diego3.9 mi
- Sharp Coronado Hospital and Hlthcr Center, Coronado4.2 mi
Straight-line miles from the center of the National City and Southeast San Diego buildings to the Census Bureau geocode of each hospital's address on the CMS hospital list.
Buildings with medical space available
| Building | Class | Built | Medical space | Largest space | Fits | Asking rent | |
|---|---|---|---|---|---|---|---|
| 502 Euclid Ave | C | 1985 | 6,113 SF4 spaces
| 2,405 SF | ~4–6 rooms | $2.54/SF/mo Full Service | |
| 2240 E Plaza Blvd | C | 1988 | 4,773 SF4 spaces
| 1,955 SF | ~3–5 rooms | Withheld ask us | |
| 2754 Imperial Ave | B | 2009 | 4,272 SF1 space
| 4,272 SF | ~7–11 rooms | Withheld ask us | |
| 1023-1145 Highland Ave South Bay Plaza | B | 1975 | 2,400 SF1 space
| 2,400 SF | ~4–6 rooms | Withheld ask us | |
| 610 Euclid Ave | C | 1990 | 1,214 SF1 space
| 1,214 SF | ~2–3 rooms | $2.42/SF/mo Full Service |
Availability and asking rates change frequently and are subject to verification. Current terms are confirmed before any tour.
Compared to nearby
| Area | Buildings | Medical space | Published asking rents ($/SF/mo, buildings) |
|---|---|---|---|
| National City and Southeast San Diego | 5 | 18,772 SF | Full Service $2.42–$2.54 (2) |
| Chula Vista | 10 | 36,768 SF | Modified Gross $2.38–$3.15 (3) · Gross + Electric $2.75 (1) · Lease type not stated $3.20 (1) |
| College Area | 15 | 75,453 SF | Modified Gross $2.35 (5) · NNN $1.25–$3.50 (5) · Gross + Utilities & Janitorial $1.75 (1) |
| Uptown, Bankers Hill and Downtown | 11 | 91,377 SF | Modified Gross $2.25–$3.65 (3) · NNN $1.95–$2.60 (3) · Gross + Utilities $2.35–$3.25 (1) |
| San Diego overall | 246 | 2,136,242 SF | NNN $1.25–$4.25 (41) · Modified Gross $1.50–$5.28 (34) · Gross + Electric $1.75–$4.45 (13) |
Lowest to highest published building asking rents, grouped by lease structure; the three most common structures are shown. Each range mixes building classes and ages. See the full rent trends report.
Questions about medical office space in National City and Southeast San Diego
How many medical office buildings have space available in National City and Southeast San Diego?
National City and Southeast San Diego has 5 buildings with medical office space available as of September 2026: 18,772 SF across 11 listed spaces. Of that, 13,885 SF is marked vacant now, and the largest single space is 4,272 SF, about 7 to 11 exam rooms.
What do medical office leases cost in National City and Southeast San Diego?
In National City and Southeast San Diego, two buildings publish an asking rent with a named lease structure, but no class has five or more on one structure, too few to call any figure typical: Class C on Full Service in two. Another three buildings post no asking rent; those landlords quote on request. Full Service includes operating costs and utilities, NNN adds taxes, insurance and common-area costs on top, and Modified Gross splits them, so compare total occupancy cost, not the headline rate.
How much space does a medical practice need in National City and Southeast San Diego?
About 385 to 600 rentable square feet per exam room. That's 350 to 500 usable square feet (the room plus its share of waiting, work areas, storage, restrooms and halls), and leases are quoted in rentable square feet, which run 10% to 20% above usable in multi-tenant medical buildings. In National City and Southeast San Diego, the listed spaces break down as 3 for 1 to 2 rooms, 5 for 3 to 4, 2 for 5 to 7 and 1 for 8 to 12.
Which hospitals are near National City and Southeast San Diego?
Paradise Valley Hospital is the closest hospital, 0.7 mile from the center of the National City and Southeast San Diego trade area. Also within 5 miles: Nmc San Diego (military), San Diego, 3.9 miles; Sharp Coronado Hospital and Hlthcr Center, Coronado, 4.2 miles. Distances are straight-line miles from the Census Bureau geocode of each hospital's address on the CMS hospital list.
How current is the National City and Southeast San Diego availability?
It's from the September 2026 survey of medical office availability. Spaces lease and asking terms change between monthly pulls, so current availability, rent and tenant improvement allowance are confirmed with each landlord before any tour.
Send me what fits in National City and Southeast San Diego
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Your advisor
Jamal Brown
Real Estate Broker · CA DRE #01780052
Jamal has spent more than 23 years in commercial real estate and has negotiated and audited more than 1,000 leases. He represents medical practices as tenants and buyers, never landlords, across Los Angeles, Orange County, San Diego and the Inland Empire. Every request sent through this site gets a reply within one business day.
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