Medical office space · data as of September 2026
Medical office space for lease in Mission Viejo
19 buildings with 181,823 SF of medical space available across 61 listed spaces. Seven buildings publish an asking rent; no class has five or more on one lease structure, too few to call a figure typical.
Mission Viejo's published rents this September come on three different lease structures, and they aren't the same kind of number: Full Service in three buildings, Modified Gross in two and NNN in two.
Full Service rolls operating costs and utilities into the rate; Modified Gross splits operating costs between landlord and tenant, lease by lease; NNN puts taxes, insurance and common-area costs on top of the rate. So a Full Service rate and a Modified Gross rate can't be compared until both are converted to total occupancy cost (rent plus everything the lease adds on top). Full Service runs $1.53 to $3.15/SF/month here, Modified Gross $3.00 to $3.50 and NNN $3.00 to $3.30.
Here's the part that gets less attention. Of the 19 buildings, 12 post no asking rent. From the real estate side, an unposted rent isn't a high rent. It's an open question, and the answer tends to move once a second building is in the conversation.
So: landlords in Mission Viejo quote three lease structures, and 12 of 19 buildings in Mission Viejo post no rent. The market you can see online is the smaller part of it. If you priced Mission Viejo today, how many of these 19 buildings would you actually have a number for?
Mission Viejo at a glance
- Buildings
- 19
- Medical space available
- 181,823 SF
- Vacant now
- 130,294 SF
- Largest single space
- 15,000 SF
Asking rents by lease structure
- Full Service$1.50–$3.15/SF/mo3 buildings
- Modified Gross$3.00–$3.50/SF/mo2 buildings
- NNN$3.00–$3.30/SF/mo2 buildings
12 buildings withhold pricing or don't publish it. Those numbers come from the landlords on request.
Full Service includes operating costs and utilities; NNN adds taxes, insurance and common-area costs on top of base rent; Modified Gross splits them. Compare structures, not just rates. These ranges span every building class and age; the questions below compare like with like.
Available spaces by size
- 1–2 rooms5
- 3–4 rooms17
- 5–7 rooms14
- 8–12 rooms6
- 13+ rooms5
Room counts assume 350 to 500 usable SF per exam room, with rentable area 10% to 20% above usable.
Building class
- Class A5
- Class B11
- Class C3
Hospitals within 5 miles
- Providence Mission Hospital, Mission Viejo1.3 mi
- Children's Hospital at Mission (children's), Mission Viejo1.3 mi
- Memorialcare Saddleback Medical Center, Laguna Hills3.1 mi
Straight-line miles from the center of the Mission Viejo buildings to the Census Bureau geocode of each hospital's address on the CMS hospital list.
Buildings with medical space available
| Building | Class | Built | Medical space | Largest space | Fits | Asking rent | |
|---|---|---|---|---|---|---|---|
| 27800 Medical Center Rd Building 3 | C | 1980 | 45,000 SF3 spaces
| 15,000 SF | ~25–38 rooms | Withheld ask us | |
| 27800 Medical Center Rd Building 2 | C | 1974 | 40,586 SF12 spaces
| 7,467 SF | ~12–19 rooms | Withheld ask us | |
| 27101 Puerta Real | A | 2000 | 19,476 SF5 spaces
| 9,898 SF | ~16–25 rooms | $1.55/SF/mo Full Service | |
| 27800 Medical Center Rd Building 1 | C | 1974 | 16,338 SF6 spaces
| 4,154 SF | ~6–10 rooms | Withheld ask us | |
| 26300 La Alameda Crown Valley Financial Plaza | B | 1982 | 9,296 SF2 spaces
| 6,624 SF | ~11–17 rooms | $3.00/SF/mo NNN | |
| 27871 Medical Center Rd Marguerite Medical | B | 1980 | 9,059 SF3 spaces
| 4,393 SF | ~7–11 rooms | Withheld ask us | |
| 26691 Plaza Dr Los Altos Plaza | B | 1990 | 9,000 SF2 spaces
| 5,000 SF | ~8–12 rooms | Withheld ask us | |
| 26732 Crown Valley Pkwy Mission Medical Tower | A | 1984 | 6,828 SF4 spaces
| 2,417 SF | ~4–6 rooms | Withheld ask us | |
| 26137 La Paz Rd La Paz Plaza | B | 1972 | 4,786 SF1 space
| 4,786 SF | ~7–12 rooms | Withheld ask us | |
| 27401 Los Altos CERRO | A | 1984 | 3,322 SF1 space
| 3,322 SF | ~5–8 rooms | $3.15/SF/mo Full Service | |
| 25982 Pala Dr Mission Hills Medical Center | B | 2005 | 3,302 SF1 space
| 3,302 SF | ~5–8 rooms | Withheld ask us | |
| 26161 La Paz Rd | B | 2017 | 2,700 SF1 space
| 2,700 SF | ~4–7 rooms | Withheld ask us | |
| 23120 Alicia Pky Lakeside Plaza | B | 1979 | 2,439 SF14 spaces
| 201 SF | Withheld ask us | ||
| 26800 Crown Valley Pky Mission Medical Plaza | A | 2007 | 1,895 SF1 space
| 1,895 SF | ~3–4 rooms | Withheld ask us | |
| 26932 Oso Pky | B | 1,850 SF1 space
| 1,850 SF | ~3–4 rooms | $3.00/SF/mo Modified Gross | ||
| 27201 Puerta Real | A | 2000 | 1,817 SF1 space
| 1,817 SF | ~3–4 rooms | $1.50–$1.55/SF/mo Full Service | |
| 26921 Crown Valley Pky Crown Valley Medical | B | 1986 | 1,643 SF1 space
| 1,643 SF | ~2–4 rooms | $3.30/SF/mo NNN | |
| 26302 La Paz Rd La Paz Medical/Dental Center | B | 1969 | 1,410 SF1 space
| 1,410 SF | ~2–3 rooms | $3.50/SF/mo Modified Gross | |
| 27725 Santa Margarita Pky Trabuco Hills Medical Center | B | 1992 | 1,076 SF1 space
| 1,076 SF | ~1–2 rooms | Withheld ask us |
Availability and asking rates change frequently and are subject to verification. Current terms are confirmed before any tour.
Compared to nearby
| Area | Buildings | Medical space | Published asking rents ($/SF/mo, buildings) |
|---|---|---|---|
| Mission Viejo | 19 | 181,823 SF | Full Service $1.50–$3.15 (3) · Modified Gross $3.00–$3.50 (2) · NNN $3.00–$3.30 (2) |
| Laguna Hills and Aliso Viejo | 17 | 137,291 SF | NNN $2.70–$3.95 (3) · Full Service $2.65–$2.75 (1) · Modified Gross $2.70 (1) |
| Rancho Santa Margarita and Ladera Ranch | 7 | 35,243 SF | NNN $1.80–$4.00 (5) · Modified Gross $2.35 (1) |
| Lake Forest and Foothill Ranch | 7 | 21,681 SF | Full Service $2.85 (1) · NNN $2.45 (1) |
| Orange County overall | 317 | 2,274,339 SF | NNN $1.15–$5.50 (67) · Modified Gross $1.25–$4.95 (49) · Full Service $1.25–$6.00 (47) |
Lowest to highest published building asking rents, grouped by lease structure; the three most common structures are shown. Each range mixes building classes and ages. See the full rent trends report.
Questions about medical office space in Mission Viejo
How many medical office buildings have space available in Mission Viejo?
Mission Viejo has 19 buildings with medical office space available as of September 2026: 181,823 SF across 61 listed spaces. Of that, 130,294 SF is marked vacant now, and the largest single space is 15,000 SF, about 25 to 38 exam rooms.
What do medical office leases cost in Mission Viejo?
In Mission Viejo, six buildings publish an asking rent with a named lease structure, but no class has five or more on one structure, too few to call any figure typical: Class A on Full Service in three, Class B on NNN in two and Class B on Modified Gross in one. Another 12 buildings post no asking rent; those landlords quote on request. Full Service includes operating costs and utilities, NNN adds taxes, insurance and common-area costs on top, and Modified Gross splits them, so compare total occupancy cost, not the headline rate.
How much space does a medical practice need in Mission Viejo?
About 385 to 600 rentable square feet per exam room. That's 350 to 500 usable square feet (the room plus its share of waiting, work areas, storage, restrooms and halls), and leases are quoted in rentable square feet, which run 10% to 20% above usable in multi-tenant medical buildings. In Mission Viejo, the listed spaces break down as 5 for 1 to 2 rooms, 17 for 3 to 4, 14 for 5 to 7, 6 for 8 to 12 and 5 for 13 or more.
Which hospitals are near Mission Viejo?
Providence Mission Hospital is the closest hospital, 1.3 miles from the center of the Mission Viejo trade area. Also within 5 miles: Children's Hospital at Mission (children's), Mission Viejo, 1.3 miles; Memorialcare Saddleback Medical Center, Laguna Hills, 3.1 miles. Distances are straight-line miles from the Census Bureau geocode of each hospital's address on the CMS hospital list.
How current is the Mission Viejo availability?
It's from the September 2026 survey of medical office availability. Spaces lease and asking terms change between monthly pulls, so current availability, rent and tenant improvement allowance are confirmed with each landlord before any tour.
Send me what fits in Mission Viejo
Send your size and timing. Live availability comes back within one business day.
Sent.
We typically reply within one business day. Prefer to talk now? Call (619) 796-3390.
Your advisor
Jamal Brown
Real Estate Broker · CA DRE #01780052
Jamal has spent more than 23 years in commercial real estate and has negotiated and audited more than 1,000 leases. He represents medical practices as tenants and buyers, never landlords, across Los Angeles, Orange County, San Diego and the Inland Empire. Every request sent through this site gets a reply within one business day.
Recent medical office deals
8 practices · 20,061 SF leased · $2.7M building purchase
- 23500 Hawthorne Blvd$2.7MTorrance · owner-user purchase, $500K below asking
- X-Ray Medical Group5,200 SFLa Mesa
- Lighthouse Pediatrics4,261 SFTorrance
- Caring Physicians3,600 SFLa Mesa
- Desert Trauma Surgeons2,000 SFLynwood
- Dr. Hannon1,600 SFBeverly Hills
- Achilles Podiatry1,200 SFLa Mesa
- Dr. Kenith Paresa1,200 SFSanta Monica
- Little Bellies1,000 SFIrvine