Medical office space · data as of September 2026
Medical office space for lease in Rancho Santa Margarita and Ladera Ranch
7 buildings with 35,243 SF of medical space available across 15 listed spaces. Six buildings publish an asking rent; no class has five or more on one lease structure, too few to call a figure typical.
Only seven buildings in Rancho Santa Margarita and Ladera Ranch list medical office space this September.
The biggest single space is 5,006 SF, about 8 to 13 exam rooms, out of 15 listed. Of those, three are sized for one or two exam rooms, 10 for three to seven and two for eight or more. Nearby, Mission Viejo lists 19 buildings and Laguna Hills and Aliso Viejo lists 17, so a search drawn tightly around Rancho Santa Margarita and Ladera Ranch is a search of seven buildings.
One more fact changes the read. Only 2 of 15 listed spaces are 4,200 SF or larger. The lease read: a practice that needs eight rooms or more here is shopping from a short list, and the landlords on it know that. Start earlier than feels necessary, and keep a second trade area in play.
Short version: Rancho Santa Margarita and Ladera Ranch is a seven-building trade area this September, and only 2 of 15 spaces are 4,200 SF or larger. Large practices here are choosing from a short list. Could your practice run across two adjacent suites, or does it need one?
Rancho Santa Margarita and Ladera Ranch at a glance
- Buildings
- 7
- Medical space available
- 35,243 SF
- Vacant now
- 27,945 SF
- Largest single space
- 5,006 SF
Asking rents by lease structure
- NNN$1.80–$4.00/SF/mo5 buildings
- Modified Gross$2.35/SF/mo1 building
1 building withholds pricing or doesn't publish it. Those numbers come from the landlords on request.
Full Service includes operating costs and utilities; NNN adds taxes, insurance and common-area costs on top of base rent; Modified Gross splits them. Compare structures, not just rates. These ranges span every building class and age; the questions below compare like with like.
Available spaces by size
- 1–2 rooms3
- 3–4 rooms6
- 5–7 rooms4
- 8–12 rooms2
- 13+ rooms0
Room counts assume 350 to 500 usable SF per exam room, with rentable area 10% to 20% above usable.
Building class
- Class B6
- Class C1
Hospitals within 5 miles
- Providence Mission Hospital, Mission Viejo4.7 mi
- Children's Hospital at Mission (children's), Mission Viejo4.7 mi
Straight-line miles from the center of the Rancho Santa Margarita and Ladera Ranch buildings to the Census Bureau geocode of each hospital's address on the CMS hospital list.
Buildings with medical space available
| Building | Class | Built | Medical space | Largest space | Fits | Asking rent | |
|---|---|---|---|---|---|---|---|
| 555 Corporate Dr | B | 2008 | 15,644 SF8 spaces
| 3,065 SF | ~5–7 rooms | $1.80–$3.15/SF/mo NNN | |
| 29472 Avenida de las Banderas | C | 2000 | 5,006 SF1 space
| 5,006 SF | ~8–13 rooms | $3.35/SF/mo NNN | |
| 29803 Santa Margarita Pky Bldg 3-Phase I | B | 2000 | 4,777 SF1 space
| 4,777 SF | ~7–12 rooms | $2.50/SF/mo NNN | |
| 777 Corporate Dr | B | 2007 | 3,261 SF2 spaces
| 2,360 SF | ~3–6 rooms | $3.15/SF/mo NNN | |
| 22032 El Paseo RSM Health Center | B | 2001 | 2,835 SF1 space
| 2,835 SF | ~4–7 rooms | Withheld ask us | |
| 29839 Santa Margarita Pky Bldg 13-Phase II | B | 2003 | 2,100 SF1 space
| 2,100 SF | ~3–5 rooms | $2.00–$4.00/SF/mo NNN | |
| 30212 Tomas Tomas Professional Center | B | 2007 | 1,620 SF1 space
| 1,620 SF | ~2–4 rooms | $2.35/SF/mo Modified Gross |
Availability and asking rates change frequently and are subject to verification. Current terms are confirmed before any tour.
Compared to nearby
| Area | Buildings | Medical space | Published asking rents ($/SF/mo, buildings) |
|---|---|---|---|
| Rancho Santa Margarita and Ladera Ranch | 7 | 35,243 SF | NNN $1.80–$4.00 (5) · Modified Gross $2.35 (1) |
| Mission Viejo | 19 | 181,823 SF | Full Service $1.50–$3.15 (3) · Modified Gross $3.00–$3.50 (2) · NNN $3.00–$3.30 (2) |
| Lake Forest and Foothill Ranch | 7 | 21,681 SF | Full Service $2.85 (1) · NNN $2.45 (1) |
| Laguna Hills and Aliso Viejo | 17 | 137,291 SF | NNN $2.70–$3.95 (3) · Full Service $2.65–$2.75 (1) · Modified Gross $2.70 (1) |
| Orange County overall | 317 | 2,274,339 SF | NNN $1.15–$5.50 (67) · Modified Gross $1.25–$4.95 (49) · Full Service $1.25–$6.00 (47) |
Lowest to highest published building asking rents, grouped by lease structure; the three most common structures are shown. Each range mixes building classes and ages. See the full rent trends report.
Questions about medical office space in Rancho Santa Margarita and Ladera Ranch
How many medical office buildings have space available in Rancho Santa Margarita and Ladera Ranch?
Rancho Santa Margarita and Ladera Ranch has 7 buildings with medical office space available as of September 2026: 35,243 SF across 15 listed spaces. Of that, 27,945 SF is marked vacant now, and the largest single space is 5,006 SF, about 8 to 13 exam rooms.
What do medical office leases cost in Rancho Santa Margarita and Ladera Ranch?
In Rancho Santa Margarita and Ladera Ranch, six buildings publish an asking rent with a named lease structure, but no class has five or more on one structure, too few to call any figure typical: Class B on NNN in four, Class B on Modified Gross in one and Class C on NNN in one. Across South Orange County, Class B buildings on NNN ask a median $3.25/SF/month. Another one building posts no asking rent; those landlords quote on request. Full Service includes operating costs and utilities, NNN adds taxes, insurance and common-area costs on top, and Modified Gross splits them, so compare total occupancy cost, not the headline rate.
How much space does a medical practice need in Rancho Santa Margarita and Ladera Ranch?
About 385 to 600 rentable square feet per exam room. That's 350 to 500 usable square feet (the room plus its share of waiting, work areas, storage, restrooms and halls), and leases are quoted in rentable square feet, which run 10% to 20% above usable in multi-tenant medical buildings. In Rancho Santa Margarita and Ladera Ranch, the listed spaces break down as 3 for 1 to 2 rooms, 6 for 3 to 4, 4 for 5 to 7 and 2 for 8 to 12.
Which hospitals are near Rancho Santa Margarita and Ladera Ranch?
Providence Mission Hospital is the closest hospital, 4.7 miles from the center of the Rancho Santa Margarita and Ladera Ranch trade area. Also within 5 miles: Children's Hospital at Mission (children's), Mission Viejo, 4.7 miles. Distances are straight-line miles from the Census Bureau geocode of each hospital's address on the CMS hospital list.
How current is the Rancho Santa Margarita and Ladera Ranch availability?
It's from the September 2026 survey of medical office availability. Spaces lease and asking terms change between monthly pulls, so current availability, rent and tenant improvement allowance are confirmed with each landlord before any tour.
Send me what fits in Rancho Santa Margarita and Ladera Ranch
Send your size and timing. Live availability comes back within one business day.
Sent.
We typically reply within one business day. Prefer to talk now? Call (619) 796-3390.
Your advisor
Jamal Brown
Real Estate Broker · CA DRE #01780052
Jamal has spent more than 23 years in commercial real estate and has negotiated and audited more than 1,000 leases. He represents medical practices as tenants and buyers, never landlords, across Los Angeles, Orange County, San Diego and the Inland Empire. Every request sent through this site gets a reply within one business day.
Recent medical office deals
8 practices · 20,061 SF leased · $2.7M building purchase
- 23500 Hawthorne Blvd$2.7MTorrance · owner-user purchase, $500K below asking
- X-Ray Medical Group5,200 SFLa Mesa
- Lighthouse Pediatrics4,261 SFTorrance
- Caring Physicians3,600 SFLa Mesa
- Desert Trauma Surgeons2,000 SFLynwood
- Dr. Hannon1,600 SFBeverly Hills
- Achilles Podiatry1,200 SFLa Mesa
- Dr. Kenith Paresa1,200 SFSanta Monica
- Little Bellies1,000 SFIrvine