Medical office space · data as of September 2026
Medical office space for lease in Downtown Los Angeles
10 buildings with 136,435 SF of medical space available across 36 listed spaces. Seven buildings publish an asking rent; no class has five or more on one lease structure, too few to call a figure typical.
In Downtown Los Angeles, five of eight buildings with medical space listed this September are less than 75% leased.
That's the whole building, not only the suite on offer. Here, four of eight buildings are less than half leased, and two are at 90% or more. A landlord with that much space to fill is paying taxes, insurance and upkeep on space that earns nothing.
The second thing to know is about price. Landlords here quote three lease structures: Full Service in two buildings, at $3.95 to $4.35/SF/month; Modified Gross in two buildings and NNN in two buildings. The lease read: convert every quote to total occupancy cost before comparing a single number. An NNN rate can look cheaper than a Full Service rate and cost more.
Short version: the median building with space listed in Downtown Los Angeles is 56% leased, and landlords there quote three lease structures. Comparing rates without converting structures compares labels. Is your current lease Full Service, NNN or Modified Gross, and do you know what it costs all in?
Downtown Los Angeles at a glance
- Buildings
- 10
- Medical space available
- 136,435 SF
- Vacant now
- 124,116 SF
- Largest single space
- 16,633 SF
Asking rents by lease structure
- Full Service$3.95–$4.35/SF/mo2 buildings
- Modified Gross$1.47–$2.00/SF/mo2 buildings
- NNN$2.35–$2.40/SF/mo2 buildings
- Lease type not stated$1.25/SF/mo1 building
3 buildings withhold pricing or don't publish it. Those numbers come from the landlords on request.
Full Service includes operating costs and utilities; NNN adds taxes, insurance and common-area costs on top of base rent; Modified Gross splits them. Compare structures, not just rates. These ranges span every building class and age; the questions below compare like with like.
Available spaces by size
- 1–2 rooms5
- 3–4 rooms11
- 5–7 rooms11
- 8–12 rooms5
- 13+ rooms4
Room counts assume 350 to 500 usable SF per exam room, with rentable area 10% to 20% above usable.
Building class
- Class A5
- Class B1
- Class C4
Hospitals within 5 miles
- PIH Health Good Samaritan Hospital, Los Angeles1.1 mi
- California Hospital Medical Center La, Los Angeles1.4 mi
- L A Downtown Medical Center, Los Angeles1.7 mi
- Adventist Health White Memorial, Los Angeles1.7 mi
- Los Angeles General Medical Center, Los Angeles2.3 mi
Straight-line miles from the center of the Downtown Los Angeles buildings to the Census Bureau geocode of each hospital's address on the CMS hospital list.
Buildings with medical space available
| Building | Class | Built | Medical space | Largest space | Fits | Asking rent | |
|---|---|---|---|---|---|---|---|
| 420 E 3rd St 10 Terraces | A | 1989 | 69,284 SF14 spaces
| 16,633 SF | ~27–43 rooms | $1.25/SF/mo | |
| 1127 Wilshire Blvd Samaritan Medical Tower | A | 1964 | 17,402 SF10 spaces
| 3,010 SF | ~5–7 rooms | $4.35/SF/mo Full Service | |
| 440 S Broadway Broadway Mall | C | 1984 | 15,422 SF1 space
| 15,422 SF | ~25–40 rooms | Withheld ask us | |
| 1513 S Grand Ave Loker Medical Arts Pavilion | A | 2010 | 9,125 SF2 spaces
| 5,416 SF | ~9–14 rooms | $2.40/SF/mo NNN | |
| 1100 Wilshire Blvd 1100 Wilshire | A | 1986 | 6,750 SF3 spaces
| 3,500 SF | ~5–9 rooms | Withheld ask us | |
| 124 N Vignes St Temple Medical Center | C | 1968 | 6,725 SF1 space
| 6,725 SF | ~11–17 rooms | $2.35/SF/mo NNN | |
| 1333 S Hill St | C | 1978 | 3,750 SF1 space
| 3,750 SF | ~6–9 rooms | $1.47/SF/mo Modified Gross | |
| 1414 S Grand Ave CMC Medical Plaza | A | 1988 | 3,547 SF2 spaces
| 2,105 SF | ~3–5 rooms | $3.95/SF/mo Full Service | |
| 5411 Valley Blvd Social Security | C | 1982 | 3,130 SF1 space
| 3,130 SF | ~5–8 rooms | $2.00/SF/mo Modified Gross | |
| 700-716 W 1st St The Promenade Residences | B | 1981 | 1,300 SF1 space
| 1,300 SF | ~2–3 rooms | Withheld ask us |
Availability and asking rates change frequently and are subject to verification. Current terms are confirmed before any tour.
Compared to nearby
| Area | Buildings | Medical space | Published asking rents ($/SF/mo, buildings) |
|---|---|---|---|
| Downtown Los Angeles | 10 | 136,435 SF | Full Service $3.95–$4.35 (2) · Modified Gross $1.47–$2.00 (2) · NNN $2.35–$2.40 (2) |
| Koreatown | 15 | 118,719 SF | Full Service $1.50–$5.45 (3) · Modified Gross $3.00–$3.25 (2) · Gross $2.00 (1) |
| Hollywood, East Hollywood and Silver Lake | 15 | 205,915 SF | NNN $2.50–$4.75 (7) · Full Service $2.00–$3.10 (2) · Modified Gross $1.95–$2.00 (2) |
| Park Mile | 5 | 27,219 SF | Modified Gross $2.25–$2.95 (4) · Full Service $2.90 (1) |
| Los Angeles overall | 849 | 6,324,965 SF | Modified Gross $1.22–$8.50 (206) · Full Service $1.15–$10.00 (176) · NNN $1.10–$7.74 (143) |
Lowest to highest published building asking rents, grouped by lease structure; the three most common structures are shown. Each range mixes building classes and ages. See the full rent trends report.
Questions about medical office space in Downtown Los Angeles
How many medical office buildings have space available in Downtown Los Angeles?
Downtown Los Angeles has 10 buildings with medical office space available as of September 2026: 136,435 SF across 36 listed spaces. Of that, 124,116 SF is marked vacant now, and the largest single space is 16,633 SF, about 27 to 43 exam rooms.
What do medical office leases cost in Downtown Los Angeles?
In Downtown Los Angeles, six buildings publish an asking rent with a named lease structure, but no class has five or more on one structure, too few to call any figure typical: Class A on Full Service in two, Class C on Modified Gross in two and Class A on NNN in one. Another three buildings post no asking rent; those landlords quote on request. Full Service includes operating costs and utilities, NNN adds taxes, insurance and common-area costs on top, and Modified Gross splits them, so compare total occupancy cost, not the headline rate.
How much space does a medical practice need in Downtown Los Angeles?
About 385 to 600 rentable square feet per exam room. That's 350 to 500 usable square feet (the room plus its share of waiting, work areas, storage, restrooms and halls), and leases are quoted in rentable square feet, which run 10% to 20% above usable in multi-tenant medical buildings. In Downtown Los Angeles, the listed spaces break down as 5 for 1 to 2 rooms, 11 for 3 to 4, 11 for 5 to 7, 5 for 8 to 12 and 4 for 13 or more.
Which hospitals are near Downtown Los Angeles?
PIH Health Good Samaritan Hospital is the closest hospital, 1.1 miles from the center of the Downtown Los Angeles trade area. Also within 5 miles: California Hospital Medical Center La, Los Angeles, 1.4 miles; L A Downtown Medical Center, Los Angeles, 1.7 miles; Adventist Health White Memorial, Los Angeles, 1.7 miles; Los Angeles General Medical Center, Los Angeles, 2.3 miles. Distances are straight-line miles from the Census Bureau geocode of each hospital's address on the CMS hospital list.
How current is the Downtown Los Angeles availability?
It's from the September 2026 survey of medical office availability. Spaces lease and asking terms change between monthly pulls, so current availability, rent and tenant improvement allowance are confirmed with each landlord before any tour.
Send me what fits in Downtown Los Angeles
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Your advisor
Jamal Brown
Real Estate Broker · CA DRE #01780052
Jamal has spent more than 23 years in commercial real estate and has negotiated and audited more than 1,000 leases. He represents medical practices as tenants and buyers, never landlords, across Los Angeles, Orange County, San Diego and the Inland Empire. Every request sent through this site gets a reply within one business day.
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