Medical office space · data as of September 2026
Medical office space for lease in South Santa Ana
6 buildings with 40,228 SF of medical space available across 21 listed spaces. Five buildings publish an asking rent; no class has five or more on one lease structure, too few to call a figure typical.
The center of the South Santa Ana buildings is 0.5 mile from Coastal Communities Hospital.
Those are straight-line miles, measured from the middle of the six buildings with space listed, which hold 40,228 SF across 21 spaces. Of the six buildings, 2 sit on Brookhollow Dr. Across the trade area, five buildings publish an asking rent, and one post no asking rent.
Here's the part that gets less attention. The newest of the six buildings went up in 1983, and five of them are Class C. From the real estate side, an older building can be the better deal, if the landlord pays to make the suite work. Ask what the plumbing, restrooms and HVAC can carry before you talk rent. The rent and the build-out are one negotiation, not two. Older buildings often have skeletons in a closet that you're paying for.
Short version: Coastal Communities Hospital sits 0.5 mile out, and the newest building went up in 1983. In an older building, the allowance matters as much as the rate. What would your next suite need that your current one doesn't have?
South Santa Ana at a glance
- Buildings
- 6
- Medical space available
- 40,228 SF
- Vacant now
- 37,981 SF
- Largest single space
- 3,800 SF
Asking rents by lease structure
- Modified Gross$1.69–$2.75/SF/mo3 buildings
- NNN$1.95–$2.50/SF/mo2 buildings
1 building withholds pricing or doesn't publish it. Those numbers come from the landlords on request.
Full Service includes operating costs and utilities; NNN adds taxes, insurance and common-area costs on top of base rent; Modified Gross splits them. Compare structures, not just rates. These ranges span every building class and age; the questions below compare like with like.
Available spaces by size
- 1–2 rooms5
- 3–4 rooms8
- 5–7 rooms8
- 8–12 rooms0
- 13+ rooms0
Room counts assume 350 to 500 usable SF per exam room, with rentable area 10% to 20% above usable.
Building class
- Class B1
- Class C5
Hospitals within 5 miles
- Coastal Communities Hospital, Santa Ana0.5 mi
- Foothill Regional Medical Center, Tustin3.0 mi
- UCI Health - Fountain Valley, Fountain Valley3.5 mi
- Orange County Global Medical Center, Santa Ana3.7 mi
- Children's Hospital of Orange County (children's), Orange4.7 mi
Straight-line miles from the center of the South Santa Ana buildings to the Census Bureau geocode of each hospital's address on the CMS hospital list.
Buildings with medical space available
| Building | Class | Built | Medical space | Largest space | Fits | Asking rent | |
|---|---|---|---|---|---|---|---|
| 2621 S Bristol St | C | 1979 | 13,700 SF7 spaces
| 3,800 SF | ~6–9 rooms | $2.00–$2.50/SF/mo NNN | |
| 1504 Brookhollow Dr | C | 1979 | 9,585 SF5 spaces
| 3,025 SF | ~5–7 rooms | $1.95–$2.00/SF/mo Modified Gross | |
| 1516 Brookhollow Dr | B | 1979 | 8,362 SF3 spaces
| 3,541 SF | ~5–9 rooms | $1.95/SF/mo NNN | |
| 1220 Hemlock Way Bristol Southcoast Centre | C | 1970 | 6,681 SF4 spaces
| 2,891 SF | ~4–7 rooms | Withheld ask us | |
| 2414 S Fairview St | C | 1983 | 1,200 SF1 space
| 1,200 SF | ~2–3 rooms | $2.05/SF/mo Modified Gross | |
| 1120 W Warner Ave | C | 1961 | 700 SF1 space
| 700 SF | ~1 room | $1.69–$2.75/SF/mo Modified Gross |
Availability and asking rates change frequently and are subject to verification. Current terms are confirmed before any tour.
Compared to nearby
| Area | Buildings | Medical space | Published asking rents ($/SF/mo, buildings) |
|---|---|---|---|
| South Santa Ana | 6 | 40,228 SF | Modified Gross $1.69–$2.75 (3) · NNN $1.95–$2.50 (2) |
| Costa Mesa | 13 | 57,603 SF | NNN $2.25–$3.17 (4) · Full Service $2.50–$2.95 (2) · Modified Gross $2.65–$2.70 (2) |
| Santa Ana Civic Center | 7 | 64,868 SF | Modified Gross $1.25–$2.80 (3) · NNN $1.15–$3.50 (2) · Full Service $1.75–$2.00 (1) |
| Fountain Valley | 7 | 48,905 SF | Full Service $3.60 (1) · Modified Gross $1.60 (1) |
| Orange County overall | 317 | 2,274,339 SF | NNN $1.15–$5.50 (67) · Modified Gross $1.25–$4.95 (49) · Full Service $1.25–$6.00 (47) |
Lowest to highest published building asking rents, grouped by lease structure; the three most common structures are shown. Each range mixes building classes and ages. See the full rent trends report.
Questions about medical office space in South Santa Ana
How many medical office buildings have space available in South Santa Ana?
South Santa Ana has 6 buildings with medical office space available as of September 2026: 40,228 SF across 21 listed spaces. Of that, 37,981 SF is marked vacant now, and the largest single space is 3,800 SF, about 6 to 9 exam rooms.
What do medical office leases cost in South Santa Ana?
In South Santa Ana, five buildings publish an asking rent with a named lease structure, but no class has five or more on one structure, too few to call any figure typical: Class C on Modified Gross in three, Class B on NNN in one and Class C on NNN in one. Another one building posts no asking rent; those landlords quote on request. Full Service includes operating costs and utilities, NNN adds taxes, insurance and common-area costs on top, and Modified Gross splits them, so compare total occupancy cost, not the headline rate.
How much space does a medical practice need in South Santa Ana?
About 385 to 600 rentable square feet per exam room. That's 350 to 500 usable square feet (the room plus its share of waiting, work areas, storage, restrooms and halls), and leases are quoted in rentable square feet, which run 10% to 20% above usable in multi-tenant medical buildings. In South Santa Ana, the listed spaces break down as 5 for 1 to 2 rooms, 8 for 3 to 4 and 8 for 5 to 7.
Which hospitals are near South Santa Ana?
Coastal Communities Hospital is the closest hospital, 0.5 mile from the center of the South Santa Ana trade area. Also within 5 miles: Foothill Regional Medical Center, Tustin, 3.0 miles; UCI Health - Fountain Valley, Fountain Valley, 3.5 miles; Orange County Global Medical Center, Santa Ana, 3.7 miles; Children's Hospital of Orange County (children's), Orange, 4.7 miles. Distances are straight-line miles from the Census Bureau geocode of each hospital's address on the CMS hospital list.
How current is the South Santa Ana availability?
It's from the September 2026 survey of medical office availability. Spaces lease and asking terms change between monthly pulls, so current availability, rent and tenant improvement allowance are confirmed with each landlord before any tour.
Send me what fits in South Santa Ana
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Your advisor
Jamal Brown
Real Estate Broker · CA DRE #01780052
Jamal has spent more than 23 years in commercial real estate and has negotiated and audited more than 1,000 leases. He represents medical practices as tenants and buyers, never landlords, across Los Angeles, Orange County, San Diego and the Inland Empire. Every request sent through this site gets a reply within one business day.
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