Medical office space · data as of September 2026
Medical office space for lease in Temecula and Murrieta
24 buildings with 120,824 SF of medical space available across 44 listed spaces. The largest like group, six Class B buildings on NNN, asks a median $2.45/SF/month.
Landlords in Temecula and Murrieta quote two different lease structures this September: NNN in six buildings and Modified Gross in five.
NNN puts taxes, insurance and common-area costs on top of the rate; Modified Gross splits operating costs between landlord and tenant, lease by lease. So a NNN rate and a Modified Gross rate can't be compared until both are converted to total occupancy cost (rent plus everything the lease adds on top). NNN runs $1.95 to $2.75/SF/month here and Modified Gross $1.75 to $2.75.
One more fact changes the read. Southwest Healthcare Rancho Springs Hospital is 1 mile from the center of the trade area. The lease read: distance to a campus is the one thing about a suite you can't build, negotiate or fix later. Pay for the location you need, and make the buildings compete on everything else.
Short version: landlords in Temecula and Murrieta quote two lease structures, and Southwest Healthcare Rancho Springs Hospital sits 1 mile out. Pay for the distance that matters and negotiate the rest. How far is your current office from the campus you use most?
Temecula and Murrieta at a glance
- Buildings
- 24
- Medical space available
- 120,824 SF
- Vacant now
- 84,702 SF
- Largest single space
- 9,326 SF
Asking rents by lease structure
- NNN$1.95–$2.75/SF/mo6 buildings
- Modified Gross$1.75–$2.75/SF/mo5 buildings
13 buildings withhold pricing or don't publish it. Those numbers come from the landlords on request.
Full Service includes operating costs and utilities; NNN adds taxes, insurance and common-area costs on top of base rent; Modified Gross splits them. Compare structures, not just rates. These ranges span every building class and age; the questions below compare like with like.
Available spaces by size
- 1–2 rooms4
- 3–4 rooms22
- 5–7 rooms11
- 8–12 rooms4
- 13+ rooms3
Room counts assume 350 to 500 usable SF per exam room, with rentable area 10% to 20% above usable.
Building class
- Class A1
- Class B21
- Class C2
Hospitals within 5 miles
- Southwest Healthcare Rancho Springs Hospital, Murrieta1.0 mi
- Loma Linda University Medical Center-Murrieta, Murrieta4.0 mi
Straight-line miles from the center of the Temecula and Murrieta buildings to the Census Bureau geocode of each hospital's address on the CMS hospital list.
Buildings with medical space available
| Building | Class | Built | Medical space | Largest space | Fits | Asking rent | |
|---|---|---|---|---|---|---|---|
| 27450 Ynez Rd | B | 1989 | 17,943 SF5 spaces
| 9,326 SF | ~15–24 rooms | $2.75/SF/mo Modified Gross | |
| 29990 Berea Rd | B | 2025 | 15,474 SF2 spaces
| 8,221 SF | ~13–21 rooms | Withheld ask us | |
| 25130 Hancock Ave | B | 2022 | 12,354 SF4 spaces
| 5,240 SF | ~8–13 rooms | Withheld ask us | |
| 25405 Hancock Ave Walsh Medical Arts Center | B | 1992 | 10,462 SF3 spaces
| 4,678 SF | ~7–12 rooms | Withheld ask us | |
| 44274 George Cushman Ct Redhawk Medical Center | B | 2002 | 8,683 SF4 spaces
| 3,235 SF | ~5–8 rooms | Withheld ask us | |
| 27699 Jefferson Ave Temecula Medical Center | B | 1991 | 6,817 SF2 spaces
| 3,937 SF | ~6–10 rooms | Withheld ask us | |
| 25467 Medical Center Dr Murrieta Pointe Medical Center | B | 2008 | 5,537 SF2 spaces
| 3,277 SF | ~5–8 rooms | Withheld ask us | |
| 25470 Medical Center Dr Golden Triangle Medical Courtyard | B | 2005 | 4,946 SF1 space
| 4,946 SF | ~8–12 rooms | Withheld ask us | |
| 44045 Margarita Rd Building 1 | B | 2015 | 4,615 SF3 spaces
| 1,654 SF | ~2–4 rooms | Withheld ask us | |
| 31515 Rancho Pueblo Rd Bldg E | B | 2007 | 3,996 SF2 spaces
| 2,011 SF | ~3–5 rooms | $2.50/SF/mo NNN | |
| 26800-26926 Cherry Hills Blvd | B | 1965 | 3,931 SF1 space
| 3,931 SF | ~6–10 rooms | $2.00–$2.25/SF/mo NNN | |
| 26900 Newport Rd | B | 1990 | 3,600 SF1 space
| 3,600 SF | ~6–9 rooms | Withheld ask us | |
| 43920 Margarita Rd Margarita Professional Bldg | B | 2007 | 2,768 SF1 space
| 2,768 SF | ~4–7 rooms | $1.80/SF/mo Modified Gross | |
| 31565 Rancho Pueblo Rd | B | 2007 | 2,439 SF1 space
| 2,439 SF | ~4–6 rooms | $2.50/SF/mo NNN | |
| 39755 Date St Medical Professional Plaza | B | 2007 | 2,204 SF1 space
| 2,204 SF | ~3–5 rooms | $2.75/SF/mo NNN | |
| 265 San Jacinto River Rd | C | 1988 | 2,070 SF2 spaces
| 1,325 SF | ~2–3 rooms | $1.85–$1.89/SF/mo Modified Gross | |
| 29645 Rancho California Rd Rancho California Medical Plaza | B | 1987 | 2,033 SF2 spaces
| 1,200 SF | ~2–3 rooms | $1.95/SF/mo NNN | |
| 25485 Medical Center Dr Rancho Springs Medical Offices | B | 1992 | 1,989 SF1 space
| 1,989 SF | ~3–5 rooms | Withheld ask us | |
| 31170 Temecula Pky Bldg 2 | B | 2015 | 1,773 SF1 space
| 1,773 SF | ~2–4 rooms | Withheld ask us | |
| 27180 Newport Rd Bldg 3 | B | 2009 | 1,750 SF1 space
| 1,750 SF | ~2–4 rooms | $2.40/SF/mo NNN | |
| 41715 Winchester Rd Jefferson Park Medical Dental Plaza | B | 1990 | 1,450 SF1 space
| 1,450 SF | ~2–3 rooms | $1.75/SF/mo Modified Gross | |
| 31737 Riverside Dr | C | 1986 | 1,400 SF1 space
| 1,400 SF | ~2–3 rooms | $1.87/SF/mo Modified Gross | |
| 31150 Temecula Pky Bldg 1 | A | 2015 | 1,300 SF1 space
| 1,300 SF | ~2–3 rooms | Withheld ask us | |
| 44066 Margarita Rd Bldg 2 | B | 2008 | 1,290 SF1 space
| 1,290 SF | ~2–3 rooms | Withheld ask us |
Availability and asking rates change frequently and are subject to verification. Current terms are confirmed before any tour.
Compared to nearby
| Area | Buildings | Medical space | Published asking rents ($/SF/mo, buildings) |
|---|---|---|---|
| Temecula and Murrieta | 24 | 120,824 SF | NNN $1.95–$2.75 (6) · Modified Gross $1.75–$2.75 (5) |
| Beaumont and Hemet | 12 | 103,608 SF | NNN $1.25–$2.00 (2) · Full Service $1.50–$2.25 (1) · Modified Gross $1.30 (1) |
| Moreno Valley and Perris | 9 | 33,938 SF | Full Service $2.00 (1) · Modified Gross $2.40–$2.70 (1) · NNN $2.00 (1) |
| Corona and Eastvale | 17 | 103,155 SF | NNN $1.35–$2.80 (7) · Modified Gross $2.20–$2.45 (5) · Full Service $1.85–$2.80 (2) |
| Inland Empire overall | 219 | 1,107,256 SF | NNN $1.10–$3.25 (75) · Modified Gross $1.20–$3.83 (57) · Full Service $1.50–$10.00 (13) |
Lowest to highest published building asking rents, grouped by lease structure; the three most common structures are shown. Each range mixes building classes and ages. See the full rent trends report.
Questions about medical office space in Temecula and Murrieta
How many medical office buildings have space available in Temecula and Murrieta?
Temecula and Murrieta has 24 buildings with medical office space available as of September 2026: 120,824 SF across 44 listed spaces. Of that, 84,702 SF is marked vacant now, and the largest single space is 9,326 SF, about 15 to 24 exam rooms.
What do medical office leases cost in Temecula and Murrieta?
In Temecula and Murrieta, Class B buildings on NNN ask $1.95 to $2.75/SF/month, with a median of $2.45, across six buildings built from 1965 to 2009. Each building counts once, at the middle of its published range. The remaining five priced buildings sit in classes and structures with fewer than five buildings each, too few to call typical. Another 13 buildings post no asking rent; those landlords quote on request. Full Service includes operating costs and utilities, NNN adds taxes, insurance and common-area costs on top, and Modified Gross splits them, so compare total occupancy cost, not the headline rate.
How much space does a medical practice need in Temecula and Murrieta?
About 385 to 600 rentable square feet per exam room. That's 350 to 500 usable square feet (the room plus its share of waiting, work areas, storage, restrooms and halls), and leases are quoted in rentable square feet, which run 10% to 20% above usable in multi-tenant medical buildings. In Temecula and Murrieta, the listed spaces break down as 4 for 1 to 2 rooms, 22 for 3 to 4, 11 for 5 to 7, 4 for 8 to 12 and 3 for 13 or more.
Which hospitals are near Temecula and Murrieta?
Southwest Healthcare Rancho Springs Hospital is the closest hospital, 1 mile from the center of the Temecula and Murrieta trade area. Also within 5 miles: Loma Linda University Medical Center-Murrieta, Murrieta, 4.0 miles. Distances are straight-line miles from the Census Bureau geocode of each hospital's address on the CMS hospital list.
How current is the Temecula and Murrieta availability?
It's from the September 2026 survey of medical office availability. Spaces lease and asking terms change between monthly pulls, so current availability, rent and tenant improvement allowance are confirmed with each landlord before any tour.
Send me what fits in Temecula and Murrieta
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Your advisor
Jamal Brown
Real Estate Broker · CA DRE #01780052
Jamal has spent more than 23 years in commercial real estate and has negotiated and audited more than 1,000 leases. He represents medical practices as tenants and buyers, never landlords, across Los Angeles, Orange County, San Diego and the Inland Empire. Every request sent through this site gets a reply within one business day.
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