Medical office space · data as of September 2026
Medical office space for lease in Main Place
12 buildings with 191,265 SF of medical space available across 50 listed spaces. Two buildings publish an asking rent; no class has five or more on one lease structure, too few to call a figure typical.
Main Place has 12 buildings with medical space listed this September, and nine of them won't put a rent on the listing.
Only two publish a direct asking rent, mostly Full Service, at $1.96/SF/month, and one more prices sublease space only. The rest quote once a practice asks, which is standard and not a warning sign. It does mean a comparison built from listings is a comparison of two buildings out of 12.
The second thing to know is about location. Children's Hospital of Orange County is 0.7 mile from the center of the trade area, and Providence St. Joseph Hospital is 0.9 mile. The lease read: distance to a campus is the one thing about a suite you can't build, negotiate or fix later. Pay for the location you need, and make the buildings compete on everything else.
So: 9 of 12 buildings in Main Place post no rent, and two hospitals sit within 0.9 mile of the center. Pay for the distance that matters and negotiate the rest. Which of those campuses do your referrals run to today?
Main Place at a glance
- Buildings
- 12
- Medical space available
- 191,265 SF
- Vacant now
- 160,898 SF
- Largest single space
- 22,212 SF
Asking rents by lease structure
- Full Service$1.96/SF/mo1 building
- NNN$3.00/SF/mo1 building
9 buildings withhold pricing or don't publish it. Those numbers come from the landlords on request.
Full Service includes operating costs and utilities; NNN adds taxes, insurance and common-area costs on top of base rent; Modified Gross splits them. Compare structures, not just rates. These ranges span every building class and age; the questions below compare like with like.
Available spaces by size
- 1–2 rooms9
- 3–4 rooms17
- 5–7 rooms12
- 8–12 rooms3
- 13+ rooms8
Room counts assume 350 to 500 usable SF per exam room, with rentable area 10% to 20% above usable.
Building class
- Class A3
- Class B5
- Class C4
Hospitals within 5 miles
- Children's Hospital of Orange County (children's), Orange0.7 mi
- Providence St. Joseph Hospital, Orange0.9 mi
- Healthbridge Children's Hospital - Orange (children's), Orange1.7 mi
- Orange County Global Medical Center, Santa Ana1.9 mi
- UCI Health-Orange, Orange2.1 mi
Straight-line miles from the center of the Main Place buildings to the Census Bureau geocode of each hospital's address on the CMS hospital list.
Buildings with medical space available
| Building | Class | Built | Medical space | Largest space | Fits | Asking rent | |
|---|---|---|---|---|---|---|---|
| 1125 E 17th St North Bldg | B | 1961 | 32,173 SF8 spaces
| 15,000 SF | ~25–38 rooms | Withheld ask us | |
| 1140 W La Veta Ave St. Joseph Medical Plaza | A | 1992 | 27,873 SF11 spaces
| 7,727 SF | ~12–20 rooms | Withheld ask us | |
| 725 W Town and Country Rd Centrum South | B | 1986 | 25,702 SF3 spaces
| 19,551 SF | ~32–50 rooms | Withheld ask us | |
| 1010 W La Veta Ave St. Joseph Hospital Medical Plaza | A | 2008 | 22,494 SF7 spaces
| 7,850 SF | ~13–20 rooms | $3.00/SF/mo NNN | |
| 1120 W La Veta Ave Centrum North | B | 1985 | 22,212 SF1 space
| 22,212 SF | ~37–57 rooms | Withheld ask us | |
| 1 City Blvd W City Plaza | A | 1969 | 21,859 SF3 spaces
| 11,908 SF | ~19–30 rooms | Withheld ask us | |
| 1125 E 17th St East Building | C | 1961 | 16,790 SF5 spaces
| 5,000 SF | ~8–12 rooms | Withheld ask us | |
| 1125 E 17th St West Bldg | C | 1961 | 9,901 SF4 spaces
| 4,196 SF | ~6–10 rooms | Withheld ask us | |
| 765 The City Drive South City Centre II | C | 1987 | 4,529 SF3 spaces
| 1,911 SF | ~3–4 rooms | Withheld ask us | |
| 1201-1223 E 17th St North Park Plaza | B | 1977 | 3,872 SF1 space
| 3,872 SF | ~6–10 rooms | Withheld ask us | |
| 2090 N Tustin Ave Richman Professional Center | B | 2002 | 3,200 SF3 spaces
| 1,500 SF | ~2–3 rooms | $2.30–$3.60/SF/mo Full Service · sublease | |
| 1625 E 17th St | C | 1975 | 660 SF1 space
| 660 SF | ~1 room | $1.96/SF/mo Full Service |
Availability and asking rates change frequently and are subject to verification. Current terms are confirmed before any tour.
Compared to nearby
| Area | Buildings | Medical space | Published asking rents ($/SF/mo, buildings) |
|---|---|---|---|
| Main Place | 12 | 191,265 SF | Full Service $1.96 (1) · NNN $3.00 (1) |
| Santa Ana Civic Center | 7 | 64,868 SF | Modified Gross $1.25–$2.80 (3) · NNN $1.15–$3.50 (2) · Full Service $1.75–$2.00 (1) |
| East Orange | 9 | 42,068 SF | Modified Gross $2.40–$4.00 (4) · Full Service $1.50–$2.49 (1) · Gross + Electric $2.00 (1) |
| Tustin and Parkcenter | 19 | 73,928 SF | Full Service $1.25–$2.40 (5) · NNN $2.15–$3.00 (3) · Modified Gross $2.75 (1) |
| Orange County overall | 317 | 2,274,339 SF | NNN $1.15–$5.50 (67) · Modified Gross $1.25–$4.95 (49) · Full Service $1.25–$6.00 (47) |
Lowest to highest published building asking rents, grouped by lease structure; the three most common structures are shown. Each range mixes building classes and ages. See the full rent trends report.
Questions about medical office space in Main Place
How many medical office buildings have space available in Main Place?
Main Place has 12 buildings with medical office space available as of September 2026: 191,265 SF across 50 listed spaces. Of that, 160,898 SF is marked vacant now, and the largest single space is 22,212 SF, about 37 to 57 exam rooms.
What do medical office leases cost in Main Place?
In Main Place, two buildings publish an asking rent with a named lease structure, but no class has five or more on one structure, too few to call any figure typical: Class C on Full Service in one and Class A on NNN in one. Another nine buildings post no asking rent; those landlords quote on request. Full Service includes operating costs and utilities, NNN adds taxes, insurance and common-area costs on top, and Modified Gross splits them, so compare total occupancy cost, not the headline rate.
How much space does a medical practice need in Main Place?
About 385 to 600 rentable square feet per exam room. That's 350 to 500 usable square feet (the room plus its share of waiting, work areas, storage, restrooms and halls), and leases are quoted in rentable square feet, which run 10% to 20% above usable in multi-tenant medical buildings. In Main Place, the listed spaces break down as 9 for 1 to 2 rooms, 17 for 3 to 4, 12 for 5 to 7, 3 for 8 to 12 and 8 for 13 or more.
Which hospitals are near Main Place?
Children's Hospital of Orange County is the closest hospital, 0.7 mile from the center of the Main Place trade area. Also within 5 miles: Providence St. Joseph Hospital, Orange, 0.9 mile; Healthbridge Children's Hospital - Orange (children's), Orange, 1.7 miles; Orange County Global Medical Center, Santa Ana, 1.9 miles; UCI Health-Orange, Orange, 2.1 miles. Distances are straight-line miles from the Census Bureau geocode of each hospital's address on the CMS hospital list.
How current is the Main Place availability?
It's from the September 2026 survey of medical office availability. Spaces lease and asking terms change between monthly pulls, so current availability, rent and tenant improvement allowance are confirmed with each landlord before any tour.
Send me what fits in Main Place
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Your advisor
Jamal Brown
Real Estate Broker · CA DRE #01780052
Jamal has spent more than 23 years in commercial real estate and has negotiated and audited more than 1,000 leases. He represents medical practices as tenants and buyers, never landlords, across Los Angeles, Orange County, San Diego and the Inland Empire. Every request sent through this site gets a reply within one business day.
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