Medical office space · data as of September 2026
4542 Ruffner St, San Diego Square One Office Plaza
1 medical office space listed, 3,628 SF in all, largest 3,628 SF (about 6 to 9 exam rooms). It's vacant now. Asking $2.40–$2.50/SF/mo on a Gross + Electric basis.
Listed spaces at 4542 Ruffner St
| Space | Use | Term |
|---|---|---|
| Suite R160 · 705 to 3,628 SF · available now | Office/Medical | Negotiable |
Sizes are rentable square feet. Listed with the building as of September 2026. Availability, asking terms and tenant improvement allowance are confirmed with the landlord before any tour.
- Medical space listed
- 3,628 SF
- Largest space
- 3,628 SF
- Fits
- ~6–9 rooms
- Vacant now
- 1 of 1
Asking rent and building facts
Asking rent
- Gross + Electric$2.40–$2.50/SF/mobuilding asking range
Kearny Mesa for comparison
- Modified Gross$1.60–$3.50/SF/mo4 buildings
- NNN$2.75/SF/mo4 buildings
- Full Service$3.35/SF/mo1 building
- Gross + Electric$2.40–$2.50/SF/mo1 building
- Gross + Utilities$1.95/SF/mo1 building
Lowest to highest published building asking rents in Kearny Mesa, grouped by lease structure. Full Service includes operating costs and utilities; NNN adds taxes, insurance and common-area costs; Modified Gross splits them.
Building
- Building classClass B
- Built1983, renovated 2004
- Stories3
- Rentable building area55,690 SF
- Parking ratio4.00 per 1,000 SF
- Leased87%
Hospitals near 4542 Ruffner St
- Sharp Memorial Hospital, San Diego1.6 mi
- Rady Children's Hospital - San Diego (children's), San Diego1.7 mi
- Kaiser Foundation Hospital - San Diego, San Diego4.2 mi
Straight-line miles from the Census Bureau geocode of each hospital's address on the CMS hospital list.
Other buildings with medical space in Kearny Mesa
- 7975 Raytheon Rd 760 SF · $1.60/SF/mo
- 3760 Convoy St Bldg 2 35,161 SF
- 3750 Convoy St 7,891 SF
- 7071 Convoy Ct Convoy Business Center 7,812 SF · $1.95/SF/mo
See every building in the Kearny Mesa trade area guide.
Questions about 4542 Ruffner St
What medical office space is available at 4542 Ruffner St?
4542 Ruffner St in San Diego lists 1 medical office space, 3,628 SF in all, as of September 2026: Suite R160 · 705 to 3,628 SF · available now. Sizes are rentable square feet.
What is the asking rent at 4542 Ruffner St?
$2.40–$2.50/SF/mo, on a Gross + Electric basis, as published for this Class B building, built in 1983 (renovated 2004).
How many exam rooms fit in the largest space at 4542 Ruffner St?
About 6 to 9. The largest listed space is 3,628 SF, and planning runs 385 to 600 rentable SF per exam room (350 to 500 usable, plus a 10% to 20% load factor, the share of common areas billed to each tenant). Plumbing, ADA restrooms and HVAC decide whether that count works in a building that wasn't built for exam rooms. This one dates to 1983, renovated 2004.
Which hospitals are near 4542 Ruffner St?
Sharp Memorial Hospital is the closest, 1.6 miles away. Also nearby: Rady Children's Hospital - San Diego (children's), San Diego, 1.7 miles; Kaiser Foundation Hospital - San Diego, San Diego, 4.2 miles. Distances are straight-line miles to each hospital's address on the CMS hospital list.
Is the availability at 4542 Ruffner St current?
It's from the September 2026 survey of medical office availability. Availability, rent and tenant improvement allowance are confirmed with the landlord before any tour.
Ask about 4542 Ruffner St
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Your advisor
Jamal Brown
Real Estate Broker · CA DRE #01780052
Jamal has spent more than 23 years in commercial real estate and has negotiated and audited more than 1,000 leases. He represents medical practices as tenants and buyers, never landlords, across Los Angeles, Orange County, San Diego and the Inland Empire. Every request sent through this site gets a reply within one business day.
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