Medical office space · data as of September 2026
280 S Main St, Orange Main Street Medical Campus II
1 medical office space listed, 19,367 SF in all, largest 19,367 SF (about 32 to 50 exam rooms). It's vacant now. The landlord quotes rent on request.
Listed spaces at 280 S Main St
| Space | Use | Term |
|---|---|---|
| Floor 2 · 5,000 to 19,367 SF · available now | Medical | Negotiable |
Sizes are rentable square feet. Listed with the building as of September 2026. Availability, asking terms and tenant improvement allowance are confirmed with the landlord before any tour.
- Medical space listed
- 19,367 SF
- Largest space
- 19,367 SF
- Fits
- ~32–50 rooms
- Vacant now
- 1 of 1
Asking rent and building facts
Asking rent
The landlord withholds pricing for this building and quotes on request.
East Orange for comparison
- Modified Gross$2.40–$4.00/SF/mo4 buildings
- Full Service$1.50–$2.49/SF/mo1 building
- Gross + Electric$2.00/SF/mo1 building
- NNN$3.90/SF/mo1 building
- Lease type not stated$1.95/SF/mo1 building
Lowest to highest published building asking rents in East Orange, grouped by lease structure. Full Service includes operating costs and utilities; NNN adds taxes, insurance and common-area costs; Modified Gross splits them.
Building
- Building classClass B
- Built2002
- Stories2
- Rentable building area44,338 SF
- Parking ratio9.74 per 1,000 SF
- Leased56%
Hospitals near 280 S Main St
- Providence St. Joseph Hospital, Orange0.2 mi
- Children's Hospital of Orange County (children's), Orange0.3 mi
- UCI Health-Orange, Orange1.4 mi
Straight-line miles from the Census Bureau geocode of each hospital's address on the CMS hospital list.
Other buildings with medical space in East Orange
- 1310 W Stewart Dr Providence Building 1,968 SF · $3.90/SF/mo
- 805 W La Veta Ave 2,300 SF · $4.00/SF/mo
- 725 W La Veta Ave 3,900 SF · $4.00/SF/mo
- 705 W La Veta Ave 941 SF · $4.00/SF/mo
See every building in the East Orange trade area guide.
Questions about 280 S Main St
What medical office space is available at 280 S Main St?
280 S Main St in Orange lists 1 medical office space, 19,367 SF in all, as of September 2026: Floor 2 · 5,000 to 19,367 SF · available now. Sizes are rentable square feet.
What is the asking rent at 280 S Main St?
Not published. The landlord quotes on request, once the size and use are known.
How many exam rooms fit in the largest space at 280 S Main St?
About 32 to 50. The largest listed space is 19,367 SF, and planning runs 385 to 600 rentable SF per exam room (350 to 500 usable, plus a 10% to 20% load factor, the share of common areas billed to each tenant). Plumbing, ADA restrooms and HVAC decide whether that count works in a building that wasn't built for exam rooms. This one dates to 2002.
Which hospitals are near 280 S Main St?
Providence St. Joseph Hospital is the closest, 0.2 mile away. Also nearby: Children's Hospital of Orange County (children's), Orange, 0.3 mile; UCI Health-Orange, Orange, 1.4 miles. Distances are straight-line miles to each hospital's address on the CMS hospital list.
Is the availability at 280 S Main St current?
It's from the September 2026 survey of medical office availability. Availability, rent and tenant improvement allowance are confirmed with the landlord before any tour.
Ask about 280 S Main St
Send your size and timing. Live availability and terms for this building come back within one business day.
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We typically reply within one business day. Prefer to talk now? Call (619) 796-3390.
Your advisor
Jamal Brown
Real Estate Broker · CA DRE #01780052
Jamal has spent more than 23 years in commercial real estate and has negotiated and audited more than 1,000 leases. He represents medical practices as tenants and buyers, never landlords, across Los Angeles, Orange County, San Diego and the Inland Empire. Every request sent through this site gets a reply within one business day.
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